ReviewInternational journal of nanomedicine2025
How Advanced Are Extracellular Vesicles in Renal Cell Carcinoma? For Diagnostic and Therapeutic Frontiers.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research advances in extracellular vesicles for diagnosis and treatment of genitourinary cancers.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal cell carcinoma (RCC), a prevalent malignant tumor of the urinary system, presents significant challenges in early diagnosis and treatment. The invasiveness of traditional tissue biopsies and the limitations of imaging techniques necessitate the exploration of novel biomarkers through liquid biopsy. Extracellular vesicles (EVs), functioning as natural nanoscale carriers, encapsulate a variety of tumor-derived molecules and exhibit distinctive potential in non-invasive diagnosis, regulation of the tumor microenvironment (TME), and resistance to treatment in RCC. Serum- and urine-derived EVs can effectively differentiate RCC patients from healthy individuals by utilizing specific biomarkers, such as miRNAs, proteins, and snoRNAs. They can predict tumor staging, metastasis, and prognosis. TME is reshaped by EVs through the transmission of immunosuppressive factors and pro-angiogenic molecules, facilitating immune escape and the formation of pre-metastatic niches. Furthermore, the drug resistance mechanisms mediated by EVs provide new insights for targeted therapy, and their application as drug carriers demonstrates therapeutic potential. Nonetheless, the clinical translation of EVs faces several technical challenges, including the standardization of isolation techniques, inadequate validation of biomarkers, and the lack of large-scale clinical studies. Future efforts are focused on integrating multi-omics analysis, AI-assisted diagnosis, and novel isolation techniques to facilitate the transition of EVs from the laboratory to clinical application. Overall, EVs hold significant promise for the precision diagnosis and treatment of RCC; however, their widespread application necessitates systematic validation and technological innovation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.