Evidence map›Paper›PMID 40949602›Full record

ReviewFrontiers in insect science2025

Panoramic view of diversity and function of cuticular proteins in insects and mosquitoes biology.

Yamini Thakur, Sanjay Tevatiya, Gaurav Kumar, Meenakshi Jeena, Vaishali Verma, Rajnikant Dixit, Shweta Pasi, Alex Eapen, Jaspreet Kaur

Abstract readReview
In one paragraph

Review in Frontiers in insect science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yamini ThakurDepartment of Vector Genomics and Vector Biology, ICMR- National Institute of Malaria Research, New Delhi, India.
Sanjay TevatiyaDepartment of Vector Genomics and Vector Biology, ICMR- National Institute of Malaria Research, New Delhi, India.
Gaurav KumarDepartment of Vector Genomics and Vector Biology, ICMR- National Institute of Malaria Research, New Delhi, India.
Meenakshi JeenaDepartment of Vector Genomics and Vector Biology, ICMR- National Institute of Malaria Research, New Delhi, India.
Vaishali VermaDepartment of Vector Genomics and Vector Biology, ICMR- National Institute of Malaria Research, New Delhi, India.
Rajnikant DixitDepartment of Vector Genomics and Vector Biology, ICMR- National Institute of Malaria Research, New Delhi, India.
Shweta PasiICMR-National Institute of Nutrition, Hyderabad, Telangana, India.
Alex EapenAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Jaspreet KaurDepartment of Vector Genomics and Vector Biology, ICMR- National Institute of Malaria Research, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The insect cuticle, vital for structural maintenance, forms their exoskeleton. It is mainly composed of an intermesh of - structural cuticle proteins (CPs) with polysaccharide chitin. The insect CPs encoded by Objective: This review recapitulates current knowledge on CPs in insects, while also underscoring vital knowledge gaps regarding regulation and metabolic crosstalk of CPs with other signaling and/or metabolic pathways. Methods: We performed a comprehensive review of published studies and extracted data from databases including Vectorbase and NCBI with the aim of retrieving information on cuticular proteins, their gene families, abundance and associated functions. Additionally, we identified and analyzed the gaps in the available information. A literature search was conducted between (2000 and 2025) in an electronic database using PubMed, Scopus and Google Scholar. The search keywords were: cuticular proteins, cuticular genes, Results: In the present review, we provide comprehensive analysis of cuticle protein families across insects including mosquitoes based on available data. We further highlight their basic constituents and protein domain structure, offering insight into their role in insect physiology. We have effectively integrated insect studies with mosquito-specific research on CPs (bridging the gap between insect and mosquito-specific research). This holistic approach would facilitate a broader comprehension of CPs in both insect and mosquito vectors. Main conclusions: The goal of this study is to enhance our understanding of insects and

Indexed as

anophelescuticle genescuticle proteinsinsectmosquitoesprotein domain

Identifiers

PMID40949602
PMCPMC12426002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.