Evidence map›Paper›PMID 40949530›Full record

ArticleJournal of biomedical optics2025

Deep learning-enabled fluorescence imaging for oral cancer margin classification in preclinical models.

Hikaru Kurosawa, Natalie J Won, Jack B Wunder, Sujit Patil, Mandolin Bartling, Esmat Najjar, Sharon Tzelnick, Brian C Wilson, Jonathan C Irish, Michael J Daly

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hikaru KurosawaUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Natalie J WonUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Jack B WunderUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Sujit PatilUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID https://orcid.org/0009-0002-8792-0143
Mandolin BartlingUniversity of Toronto, Department of Otolaryngology-Head and Neck Surgery, Toronto, Ontario, Canada.
Esmat NajjarUniversity of Toronto, Department of Otolaryngology-Head and Neck Surgery, Toronto, Ontario, Canada.
Sharon TzelnickUniversity of Toronto, Department of Otolaryngology-Head and Neck Surgery, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-7973-3212
Brian C WilsonUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-5543-666X
Jonathan C IrishUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Michael J DalyUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-2217-4146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Oral cancer surgery demands precise margin delineation to ensure complete tumor resection (healthy tissue margin Aim: A deep learning (DL)-enabled spatial frequency domain imaging (SFDI) system is investigated to provide subsurface depth quantification of fluorescent inclusions. Approach: A diffusion theory-based numerical simulation of SFDI was used to generate synthetic images for DL training. ResNet and U-Net convolutional neural networks were developed to predict margin distance (subsurface depth) and fluorophore concentration from fluorescence images and optical property maps. Validation was conducted using Results: For oral cancer optical properties, the U-Net DL model predicted the overall depth, concentration, and closest depth with errors of Conclusions: A DL-enabled SFDI system trained with

Indexed as

Deep LearningMargins of ExcisionMouth NeoplasmsOptical ImagingAnimalsComputer SimulationHumansImage Processing, Computer-AssistedPhantoms, Imagingdeep learningdepth-resolved fluorescence imagingmolecular guided surgeryoral cancer surgeryspatial frequency domain imaging

Identifiers

PMID40949530
PMCPMC12431673

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.