Evidence map›Paper›PMID 40949480›Full record

ArticleEcancermedicalscience2025

BRCA mutation and multiple primary malignancies: a rare case of recurring triple-negative breast cancer and cervical cancer.

Meryem Naciri, Fatima Ezzahra Aouzah, Adil El Ghanmi, Bouchra Ghazi, Karima Fichtali, Sqalli Houssaini Mohammed, Fadila Kouhen

Abstract readCase Reports
In one paragraph

Article in Ecancermedicalscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meryem NaciriMohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Rabat 10100, Morocco.
Fatima Ezzahra AouzahMohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca 20230, Morocco.
Adil El GhanmiDepartment of Radiotherapy, International University Hospital Cheikh Khalifa, Casablanca 20230, Morocco.
Bouchra GhaziDepartment of Radiotherapy, International University Hospital Cheikh Khalifa, Casablanca 20230, Morocco.
Karima FichtaliDepartment of Radiotherapy, International University Hospital Cheikh Khalifa, Casablanca 20230, Morocco.
Sqalli Houssaini MohammedDepartment of Radiotherapy, International University Hospital Cheikh Khalifa, Casablanca 20230, Morocco.
Fadila KouhenMohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Rabat 10100, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the BRCA1 and BRCA2 genes significantly increase the risk of hereditary cancers, mainly of the breast and ovary, but also of other cancers such as those of the pancreas, prostate and cervix. In carriers of these mutations, multiple primary malignancies (MPM) represent a complex clinical challenge, influenced by genetic and environmental factors, as well as previous cancer treatments. The case reports a patient with a BRCA1 mutation with a family history of breast and ovarian cancer and who developed cervical cancer then recurrent triple-negative breast cancer treated with mastectomy, radiotherapy, chemotherapy and Poly (Adenosine diphosohate-ribose) polymérase inhibitors. This case underlines the interplay between different malignancies in the context of breast cancer mutations and the importance of specific and personalised treatment of patients with multiple primary malignancies.

Indexed as

BRCA- breast cancer- multiple primary malignancies

Identifiers

PMID40949480
PMCPMC12426494

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.