ArticleWorld journal of gastrointestinal surgery2025
Preoperative interleukin-17a as a predictor of acute pancreatitis after pancreaticoduodenectomy.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute pancreatitis (AP) is a potentially life-threatening complication of pancreaticoduodenectomy that increases morbidity and mortality in patients. Interleukin-17A (IL-17a) the potential preoperative marker for predicting postoperative outcomes. The purpose of this study is to retrospectively assess the prognostic value of preoperative IL-17a level in prediction of AP and related postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy.
aimTo retrospectively assess the prognostic value of preoperative IL-17a levels in predicting AP and related POPF following pancreaticoduodenectomy.
methodsRetrospective analysis of pancreaticoduodenectomies performed on patients 150 patients between 2017 and 2023. Clinical data including pre-operative IL-17a levels were collected. The primary composite outcomes were postoperative AP and postoperative pancreatic (PP), and the predictive performances of IL-17a levels and fluid load status for postoperative complications were evaluated by statistical analysis.
resultsA total of 150 patients were included, and 26 patients (17.3%) developed postoperative AP and 34 patients (22.7%) developed PP. Preoperative IL-17a was a risk factor for postoperative AP (
conclusionPreoperative IL-17a levels and intravascular volume status may serve as useful predictors of AP and subsequent PP following PD. These parameters provide means to evaluate preoperative risk and may guide clinical decision making to enhance postoperative recovery.
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