Evidence map›Paper›PMID 40949289›Full record

ArticleACS omega2025

Biological Merits and Antibiofilm Mechanisms of Action of a Specially Designed Double-Shelled Microparticle.

Chengju Sheng, Chao Zhou, Mingming Guo, David C McGiffin, David M Kaye, Vinh X Truong, Changrui Qian, Xenia Kostoulias, Anton Y Peleg, John S Forsythe and 2 more

Abstract read
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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chengju ShengDepartment of Materials Science and Engineering, Monash University, Melbourne 3800, Victoria, Australia.ORCID https://orcid.org/0009-0007-9535-9508
Chao ZhouSchool of Medical and Health Engineering, Changzhou University, Changzhou 213164, Jiangsu, China.ORCID https://orcid.org/0000-0002-8952-8690
Mingming GuoSchool of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.ORCID https://orcid.org/0000-0002-5456-8027
David C McGiffinDepartment of Cardiothoracic Surgery, The Alfred and Monash University, Melbourne 3004, Victoria, Australia.
David M KayeDepartment of Cardiology, the Alfred Hospital and Monash Alfred Baker Centre for Cardiovascular Research, Monash University, Melbourne 3004, Australia.
Vinh X TruongAgency for Science, Technology and Research (A*STAR), Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore.ORCID https://orcid.org/0000-0001-5553-6097
Changrui QianInfection Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.
Xenia KostouliasInfection Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.
Anton Y PelegInfection Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.
John S ForsytheDepartment of Materials Science and Engineering, Monash University, Melbourne 3800, Victoria, Australia.ORCID https://orcid.org/0000-0003-2849-229X
Timothy F ScottDepartment of Materials Science and Engineering, Monash University, Melbourne 3800, Victoria, Australia.ORCID https://orcid.org/0000-0002-5893-3140
Yue QuInfection Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.ORCID https://orcid.org/0000-0002-4683-708X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently fabricated a double-shelled microparticle (DSMP) incorporating a quaternary ammonium compound (QAC) and quinine, which demonstrated promising anti-infective properties. In this study, we aimed to elucidate biological merits and antibiofilm mechanisms of action of the specifically designed DSMP. Antimicrobial activities of the DSMP against 32 Gram-positive clinical isolates and laboratory strains were assessed by determining the minimum inhibitory concentrations (MICs). Antibiofilm efficacies of the DSMP were evaluated by using a tetrazolium salt reduction assay and confocal laser scanning microscopy. The fractional inhibitory concentration index was determined to clarify drug-drug interactions between QAC and quinine. Evolution of DSMP resistance was experimentally assessed by using an adaptive laboratory evolutionary assay. Molecular mechanisms underlying DSMP resistance was investigated by whole genome sequencing. The DSMP demonstrated strong activity against antibiotic-susceptible clinical isolates of

Identifiers

PMID40949289
PMCPMC12423863

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.