Evidence map›Paper›PMID 40949276›Full record

ArticleACS omega2025

Novel Sulfonamide Derivatives as Anticancer Agents, VEGFR‑2 Inhibitors, and Apoptosis Triggers: Design, Synthesis, and Computational Studies.

Shatha Hallal Al-Ziyadi, Ahmed H Halawa, Amany Belal, Nisreen Khalid Aref Albezrah, Ahmad J Obaidullah, Nashwa S Abdelshafi, Hossa F Al-Shareef, Ahmed B M Mehany, Saber M Hassan, Walid E Elgammal

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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shatha Hallal Al-ZiyadiDepartment of Obstetric & Gynecology/College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Ahmed H HalawaChemistry Department, Faculty of Science (Boys), Al-Azhar University, P.O. Box 11884 Nasr City, Cairo, Egypt.
Amany BelalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID https://orcid.org/0000-0003-1045-0163
Nisreen Khalid Aref AlbezrahDepartment of Obstetric & Gynecology. College of Medicine, Taif University, P.O. Box 11099, Taif 21944. Saudi Arabia.
Ahmad J ObaidullahDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0000-0002-7532-6318
Nashwa S AbdelshafiChemistry Department, Faculty of Education, Ain Shams University, Roxy, 11711 Cairo, Egypt.
Hossa F Al-ShareefDepartment of Chemistry, Faculty of Sciences, Umm Al-Qura University, P.O. Box 21955 Mecca, Makkah, Saudia Arabia.ORCID https://orcid.org/0000-0001-9758-0408
Ahmed B M MehanyZoology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Saber M HassanChemistry Department, Faculty of Science (Boys), Al-Azhar University, P.O. Box 11884 Nasr City, Cairo, Egypt.
Walid E ElgammalChemistry Department, Faculty of Science (Boys), Al-Azhar University, P.O. Box 11884 Nasr City, Cairo, Egypt.ORCID https://orcid.org/0000-0002-5982-5635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular endothelial growth factor receptor-2 (VEGFR-2) plays a pivotal role in angiogenesis and tumor progression. Targeting VEGFR-2 remains a validated strategy for anticancer drug development.

objectiveThis study aimed to design, synthesize, and evaluate a novel series of sulfonamide derivatives as potential VEGFR-2 inhibitors with anticancer activity.

methodsA series of sulfonamide derivatives were synthesized through multistep organic reactions. Their structures were confirmed by spectroscopic methods. In vitro antiproliferative activity was evaluated against HCT-116, HepG-2, and MCF-7 cancer cell lines using MTT assays. Selectivity was assessed via cytotoxicity against normal WI-38 fibroblasts. Compounds showing potent anticancer activity were further examined for VEGFR-2 and EGFR kinase inhibition, cell cycle progression, and apoptosis induction. Molecular docking and in silico ADMET/toxicity analyses supported the pharmacological evaluation.

resultsAmong the tested compounds,

conclusionCompounds

Identifiers

PMID40949276
PMCPMC12423892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.