ArticleACS omega2025
Keratin-Functionalized Transfersomes for Improving the Skin Permeation and Deposition of Podophyllotoxin.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Skin Barrier-Informed Topical and Transdermal Drug Delivery: Excipient-Driven Strategies, Vehicle Transformation, and Translational Challenges.Pharmaceutics · 2026Review
- Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems.International journal of nanomedicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Podophyllotoxin (POD) serves as the primary therapeutic agent for the external management of genital warts. However, traditional POD tinctures often cause severe systemic adverse reactions, due to the drug being absorbed through the skin into the bloodstream. Therefore, it is particularly important to develop new topical preparations for POD to enhance topical administration and reduce systemic absorption. Herein, POD-loaded keratin-functionalized transfersomes (POD-KTFs) were developed and characterized, and the skin permeation and deposition, the intradermal fluorescence distribution, and the influence of POD-KTFs on a skin structure were evaluated. The hydrodynamic diameter and surface potential of POD-KTFs were 183.1 nm and -33.9 mV, respectively. The image of scanning electron microscopy (SEM) indicated that the POD-KTFs had a spherical appearance. The X-ray diffraction (XRD) pattern confirmed that POD mainly existed in its amorphous form in POD-KTFs. Meaningfully, POD-KTFs increased the deposition of POD in porcine ear skin by 2.14 and 1.80 times, respectively, compared to the POD tincture and POD-loaded transfersomes (POD-TFs), while the transdermal penetration of POD in POD-KTFs was obviously less than that of POD tincture (
Identifiers
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Registered trials
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