Evidence map›Paper›PMID 40949174›Full record

ArticleCurrent developments in nutrition2025

Gene-Diet Interaction Analysis in UK Biobank Identified Genetic Loci That Modify the Association Between Fish Oil Supplementation and the Incidence of Dementia.

Yueqi Lu, Huifang Xu, Yitang Sun, Susan Adanna Ihejirika, Charleston Wk Chiang, Burcu F Darst, Suhang Song, Ye Shen, Kaixiong Ye

Abstract read
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Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Yueqi LuDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, United States.
Huifang XuDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, United States.
Yitang SunDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, United States.
Susan Adanna IhejirikaInstitute of Bioinformatics, University of Georgia, Athens, Georgia, United States.
Charleston Wk ChiangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States.
Burcu F DarstPublic Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, United States.
Suhang SongDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, Georgia, United States.
Ye ShenDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, United States.
Kaixiong YeDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, United States.

Funding

Gene-Environment Interactions in Human Evolution and Complex TraitsR35GM143060 · NIGMS · UNIVERSITY OF GEORGIA · PI YE, KAIXIONG · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM143060
6 · The paper itself

Abstract

Background: Dementia is a common disease influenced by both genetic and environmental factors. Objectives: To identify additional genetic factors with modifying effects, we performed a genome-wide scan. Methods: We performed genome-wide association studies (GWAS) of incident all-cause dementia, Alzheimer's disease, and vascular dementia in 357,631 participants from UK Biobank and the FOS subgroups. Single-nucleotide polymorphisms (SNPs) suggestively associated with dementia ( Results: Time-to-event GWAS identified 6, 5, and 2 genome-wide significant loci ( Conclusions: In total, 43 genetic loci modify the association between FOS and dementia. These findings indicate a need for genome-informed personalized nutrition of FOS for the purpose of dementia prevention.

Indexed as

dementiafish oil supplementationgene-by-environment interactionsprospective cohort studytime-to-event GWAS

Identifiers

PMID40949174
PMCPMC12423404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.