ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Prevalence and Comorbidity Network Analysis of Obesity and Related Complications: A Real-World Study Based on 233,004 Individuals.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coptidis Rhizoma for Obesity, Diabetes, and Dyslipidemia: An Integrated Meta-Analysis and In Silico Study.International journal of molecular sciences · 2026Pooled it
- Understanding the socio-economic and health burden of obesity: a 10-year retrospective analysis of population-wide administrative healthcare data.Reviews in endocrine & metabolic disorders · 2026Review
- Association of Early Postoperative Biochemical Markers with a Composite Adverse Perioperative Outcome After Bariatric Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Glucagon-like Peptide-1 Receptor Agonists and Dual Incretin Therapies Across HFpEF and Cardiovascular Outcomes Trials in Patients with Obesity.Medicina (Kaunas, Lithuania) · 2026Review
- Usefulness of a virtual reality programme for body self-image in obese and overweight patients: a focus on gender differences - a randomised trial.Archives of public health = Archives belges de sante publique · 2026Article
- Resistant and Refractory Obesity: The Complexity of Anti-Obesity Therapy Failure.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To determine the prevalence of overweight/obesity and their major complications, and to map comorbidity relationships by means of large-scale, real-world data. Patients and Methods: This cross-sectional study included individuals undergoing routine health examinations from January 2021 to April 2024. Clinical and demographic data were systematically collected. Obesity-related complications were diagnosed using standardized criteria. Descriptive statistics assessed prevalence; correlation and network analyses characterized comorbidity relationships. Results: A total of 233,004 participants (57.5% male; mean age 43.51 ± 13.28 years) were enrolled. Among these, 41.1% were overweight and 6.1% had obesity. The most prevalent complications were dyslipidemia (30.9%), fatty liver disease (26.4%), and hyperuricemia (20.0%). Over 60% of participants had at least one obesity-related comorbidity. Network analysis indicated a central disease cluster comprising overweight/obesity, fatty liver disease, hypertension, diabetes, and carotid plaque, with diabetes playing a key role linking metabolic abnormalities to cardiovascular risks. Conclusion: Overweight prevalence was high in this large-scale examined population and frequently coexisted with multiple metabolic and cardiovascular conditions. Network analysis highlighted diabetes as a central condition, supporting early targeted interventions for overweight individuals to reduce obesity-related chronic disease burden.
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