Evidence map›Paper›PMID 40948986›Full record

ReviewThe EPMA journal2025

Advanced 3PM strategies in traditional Chinese medicine gels for wound healing integrating 3D/4D printing, network pharmacology and multiomics technologies.

Shengjian Ni, Wenyang Zhao, Karthikeyan Elumalai, Palanirajan Vijayaraj Kumar

Abstract readReview
In one paragraph

Review in The EPMA journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shengjian NiDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, No. 1, Jalan Menara Gading, Taman Connaught, Cheras, 56000 Kuala Lumpur, Malaysia.
Wenyang ZhaoDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, No. 1, Jalan Menara Gading, Taman Connaught, Cheras, 56000 Kuala Lumpur, Malaysia.
Karthikeyan ElumalaiSaveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105 India.ORCID 0000-0002-6259-5332
Palanirajan Vijayaraj KumarDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, No. 1, Jalan Menara Gading, Taman Connaught, Cheras, 56000 Kuala Lumpur, Malaysia.ORCID 0000-0003-1129-7084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review examines advanced predictive, preventive, and personalized medicine (3PM) strategies, along with the targeted modern approach for enhancing the performance and clinical utility of traditional Chinese medicine (TCM) gels for wound healing. These strategies are based on recent technological advancements involving 3D/4D printing, network pharmacology and multiomics technologies. TCM gels, characterized by their multicomponent and multitarget mechanisms, hold great potential for addressing the diverse challenges in the wound healing process, including inflammation, angiogenesis disorders and microbial infections. Their therapeutic effects are optimized through the modernization of classical TCM formulas, innovative design of matrix materials and functionalized drug delivery techniques. The underlying mechanisms of TCM gels are elucidated using multiomics technologies, while clinical translation focuses on standardization, quality control and rigorous clinical trial design. Future directions may include personalized treatment plans, care for complex wounds and the integration of environmentally sustainable and smart technologies. To achieve broader utilization in modern wound healing, challenges related to standardization and regulatory compliance must be addressed. The successful incorporation of TCM gels into current wound care systems can significantly contribute to public health, supporting the goal of ensuring healthy lives and promoting well-being for all. Graphical Abstract:

Indexed as

3D/4D printingCoQ10Functionalized drug deliveryInnovative matrix materialsMitochondria-centric dermatologyMitochondrial health and protectionMultiomics technologiesNetwork pharmacologyPersonalized treatmentPredictive preventive personalized medicine (PPPM / 3PM)Public healthRegulatory complianceSmart-responsive materialsTraditional Chinese medicine gelsWound healing

Identifiers

PMID40948986
PMCPMC12423390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.