Evidence map›Paper›PMID 40948983›Full record

ArticleThe EPMA journal2025

Establishment of reference intervals for serum immunoglobulin G

Changyu Liu, Yinghao Wang, Xingang Li, Xiaojia Xu, Ruirui Xu, Cuihong Tian, Zhixian Chen, Xinxia Lu, Yuejin Li, Meng Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EPMA journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Changyu LiuSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Yinghao WangSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Xingang LiNutrition and Health Innovation Research Institute & School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Xiaojia XuNutrition and Health Innovation Research Institute & School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Ruirui XuNutrition and Health Innovation Research Institute & School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Cuihong TianDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Zhixian ChenNutrition and Health Innovation Research Institute & School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Xinxia LuSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Yuejin LiSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Meng WangSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Zhaoyang TangSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Xueyu ChenSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Guoyong DingSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Xuerui TanHuman Phenome Institute, Shantou University Medical College, Shantou, China.
Dong LiSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Haifeng HouSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.
Wei WangSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 6699 Qingdao Road, Jinan, 250117 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Immunoglobulin G (IgG) Methods: The healthy participants aged 18 years and above were recruited from Shandong and Guangdong provinces. Serum IgG Results: A total of 927 participants (median age 52 years; 566 women and 361 men) were included. Of 24 glycan peaks, 14 differed significantly between sexes, and 18 varied by age. Age- and sex-specific RIs were independently calculated for all 24 glycan peaks. For key glycosylation features, the RIs were 87.37-97.63% for fucosylation, 11.08-21.69% for bisecting Conclusions: This study identified and verified significant age- and sex-related differences in IgG Supplementary Information: The online version contains supplementary material available at 10.1007/s13167-025-00416-5.

Indexed as

Abnormal glycosylation profilesDisease riskHealthy adultsImmunoglobulin GN-GlycanPredictive Preventive Personalized medicine (PPPM / 3PM)Proactive medical approachReference intervalsStratified preventionTailored intervention

Identifiers

PMID40948983
PMCPMC12423389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.