Evidence map›Paper›PMID 40948941›Full record

ReviewResearch (Washington, D.C.)2025

Lactylation in Tumor Immune Escape and Immunotherapy: Multifaceted Functions and Therapeutic Strategies.

Qing Li, Runkang Zhao, Yang Shen, Dandan Guo, Lvdan Deng, Rongbing Cai, Zhijun Shen, Zhao Xie, Na Hang, Sentao Fu and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Dual metabolic checkpoint blockadeBioactive materials · 2027
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qing LiDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Runkang ZhaoSchool of Stomatology, Dalian Medical University, Dalian 116044, PR China.
Yang ShenDepartment of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Dandan GuoDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Lvdan DengDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Rongbing CaiThe Second Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Zhijun ShenDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Zhao XieDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Na HangDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Sentao FuDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Dehuan ZhangThe First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Yihang XuThe First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Zhao HuangHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bufu TangDepartment of Interventional Radiology, Zhongshan Hospital, Shanghai Institute of Medical Imaging, Shanghai Institution of Medical Imaging, Shanghai, National Clinical Research Center of Interventional Medicine, Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0009-0003-0872-2956
Ling WangDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since its initial identification in 2019, lactylation has emerged as a critical posttranslation modification, attracting substantial research interest due to its diverse roles in biological processes. Lysine lactylation represents a recently characterized posttranslational modification wherein lactate moieties are covalently attached to protein lysine residues through both enzymatic and nonenzymatic pathways. Lactate, a primary glycolytic product, suggests a link between cell metabolism and protein function regulation. In neoplastic tissues, the Warburg effect induces preferential glucose-to-lactate metabolism in cancer cells, establishing hypoxic conditions and elevated lactate concentrations as defining characteristics of the tumor microenvironment. Extensive research has demonstrated lactate's pivotal role in tumor metastasis and patient outcomes, particularly through its influence on tumor immune microenvironment remodeling, although the precise molecular mechanisms remain under investigation. The characterization of lysine lactylation provides a novel framework for understanding these mechanisms and presents innovative opportunities for therapeutic intervention. This review examines the influence of lactylation on the tumor microenvironment and its effect in various malignancies and explores emerging therapeutic strategies, including genetic manipulation, small-molecule inhibitors, clinical pharmaceuticals, and nanoparticle-based approaches, offering new perspectives in cancer treatment.

Identifiers

PMID40948941
PMCPMC12423509

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.