Evidence map›Paper›PMID 40948935›Full record

ArticleResearch (Washington, D.C.)2025

Elevated Dickkopf 3 Promotes Abdominal Aortic Aneurysm Formation via Modulated Phenotype Switch of Vascular Smooth Muscle Cells.

Xuejie Cao, Jinmeng Jia, Qiuyue Gao, Jiaping Tao, Ming Wei, Yanting Song, Hong Wu, Shiyu Jiao, Xinxin Zhu, Xuegong Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xuejie CaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Jinmeng JiaBioinformatics Division of BRNIST and Department of Automation, MOE Key Lab of Bioinformatics, Tsinghua University, Beijing 100084, China.
Qiuyue GaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Jiaping TaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Ming WeiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Yanting SongDepartment of Pathology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China.
Hong WuDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Shiyu JiaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Xinxin ZhuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Xuegong ZhangBioinformatics Division of BRNIST and Department of Automation, MOE Key Lab of Bioinformatics, Tsinghua University, Beijing 100084, China.
Yi FuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Yuan WangBeijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
Jie DuBeijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
Qingbo XuDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Aijuan QuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
Baoqi YuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.ORCID https://orcid.org/0009-0005-5150-2507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a potentially fatal vascular disease with no effective therapeutic intervention. Vascular smooth muscle cell (VSMC) phenotypic switching and elevated matrix metalloproteinase (MMP) levels are key pathogeneses of AAA, although the underlying regulatory mechanisms remain to be fully elucidated. In our study, single-cell RNA-sequencing data analysis demonstrated a substantial elevation in modulated VSMCs in patients with aortic aneurysm, accompanied by Dickkopf 3 (DKK3) up-regulation. Both systemic DKK3 knockout and VSMC-specific DKK3 knockdown led to a marked decrease in both the incidence and mortality of AAA in mice. Reintroduction of DKK3 in

Identifiers

PMID40948935
PMCPMC12423507

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.