Evidence map›Paper›PMID 40948791›Full record

ArticleFrontiers in immunology2025

IgT and IgD dominance in the teleost central nervous system.

Samuel Vicente-Gil, Valeria Pianese, Esther Morel, Beatriz Abós, Pablo Jiménez-Barrios, Pedro Perdiguero, Diana Martín, Rocío Simón, Simona Picchietti, Giuseppe Scapigliati and 1 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuel Vicente-GilFish Immunology and Pathology Group, Biotechnology Department, National Institute for Agricultural and Food Research and Technology (INIA), Spanish Research Council (CSIC), Madrid, Spain.
Valeria PianeseDepartment for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo, Italy.
Esther MorelFish Immunology and Pathology Group, Biotechnology Department, National Institute for Agricultural and Food Research and Technology (INIA), Spanish Research Council (CSIC), Madrid, Spain.
Beatriz AbósFish Immunology and Pathology Group, Biotechnology Department, National Institute for Agricultural and Food Research and Technology (INIA), Spanish Research Council (CSIC), Madrid, Spain.
Pablo Jiménez-BarriosFish Immunology and Pathology Group, Biotechnology Department, National Institute for Agricultural and Food Research and Technology (INIA), Spanish Research Council (CSIC), Madrid, Spain.
Pedro PerdigueroDepartment of Genetics, Physiology and Microbiology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.
Diana MartínFish Immunology and Pathology Group, Biotechnology Department, National Institute for Agricultural and Food Research and Technology (INIA), Spanish Research Council (CSIC), Madrid, Spain.
Rocío SimónAnimal Health Research Center (CISA), National Institute for Agricultural and Food Research and Technology (INIA), Spanish Research Council (CSIC), Madrid, Spain.
Simona PicchiettiDepartment for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo, Italy.
Giuseppe ScapigliatiDepartment for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo, Italy.
Carolina TafallaFish Immunology and Pathology Group, Biotechnology Department, National Institute for Agricultural and Food Research and Technology (INIA), Spanish Research Council (CSIC), Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although initially described as an immune-privileged site, the central nervous system (CNS) is now known to harbor a resident immune system, composed of different innate and adaptive cell types that maintain tissue homeostasis, are regulated in pathological conditions or brain injury and are in connection with the peripheral immune system. However, information regarding a characterization of the B cell subsets colonizing the CNS or their precise role is very scarce in mammals and even more in fish. Teleost fish exclusively express IgM, IgD and the teleost-specific IgT and their expression patterns in B cells define diverse B cell subsets. IgM is the main Ig isotype in systemic responses, while previous evidence suggested a mucosally dedicated role for IgT. Recent work by our group and others, also pointed to a role for IgD in maintaining mucosal homeostasis. However, in the current study, we demonstrate through different techniques that IgD

Indexed as

B-LymphocytesB-Lymphocyte SubsetsCentral Nervous SystemFishesFish ProteinsImmunoglobulin DImmunoglobulinsAnimalsReceptors, Antigen, B-CellFish ProteinsImmunoglobulin DImmunoglobulinsimmunoglobulin T, teleostReceptors, Antigen, B-CellB cellscentral nervous systemIgDIgTrainbow troutteleost

Identifiers

PMID40948791
PMCPMC12425738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.