ArticleCardiovascular diagnosis and therapy2025
Gender-specific differences in body mass index and cardiovascular risk adversely impact survival after aortic valve replacement.
Article in Cardiovascular diagnosis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: There is a lack of evidence on association between gender specific differences in obesity and cardiovascular risk after isolated surgical aortic valve replacement (AVR) and its impact on outcomes and long-term survival. The aim of this study was to assess the impact of obesity on perioperative outcomes and long-term survival after isolated AVR. Methods: In this retrospective, single-centre study, we included all patients who underwent isolated AVR between April 2000 and December 2019 from the cardiac surgery database of the Southampton General Hospital (Patient Administration System, e-CAMIS, Yeadon, Leeds, UK). Patients with infective endocarditis, re-sternotomy, other concomitant cardiac procedures, homografts, autografts and emergency operations were excluded. Univariable regression analysis was performed to identify predictors of in-hospital mortality. Hazard ratios were calculated using a Cox proportional hazards model. Results: Total of 2,398 patients were included in the study and two groups of patients were compared: body mass index (BMI) 25-34.9 kg/m Conclusions: Obesity with composite risk factors (hypertension, diabetes mellitus and active smoking) is associated with adverse survival. We did not observe gender-specific differences in long-term survival among specific BMI groups of patients.
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