Evidence map›Paper›PMID 40948585›Full record

ArticleMaterials today. Bio2025

Aminoguanidine-assembled functional DNA tetrahedron alleviates acute lung injury by targeting the cGAS-STING signaling pathway.

Yue Chen, Di Wu, Quan Li, Zhenghua Wei, Qian Liu, Jin Li, Daohui Gong, Chaowang Huang, Qianyi You, Hang Qian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue ChenDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Di WuDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Quan LiDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Zhenghua WeiDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Qian LiuLaboratory of Pharmacy and Chemistry, and Laboratory of Tissue and Cell Biology, Lab Teaching & Management Center, Chongqing Medical University, Chongqing, 400016, China.
Jin LiDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Daohui GongDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Chaowang HuangDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Qianyi YouDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Hang QianDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Guansong WangDepartment of Pulmonary and Critical Care Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) cause severe lung inflammation and damage, compromising respiratory function. Nanomedicine offers hope in controlling this inflammation. DNA nanostructures, as drug carriers, stand out due to their non-toxic, programmable, and precisely controllable traits. However, they face challenges in physiological stability and functionalization as carriers. Here, we introduce TET

Indexed as

ALI/ARDSAminoguanidineDNA nanostructureSelf-assembly

Identifiers

PMID40948585
PMCPMC12423596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.