ArticleiScience2025
Focused ultrasound-induced blood-brain barrier opening promotes glioprotective phenotypes in ACSA-II+ murine astrocytes.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Amyloid-Frontiers in neuroscience · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) is a well-established neuroimmune modulation and drug delivery enhancement tool capable of effecting cellular, cognitive, and pathological benefits in the brain. However, the cellular mechanisms underlying these bioeffects remain incompletely characterized, motivating the present study investigating the role of a critical glial cell type: astrocytes. Here, we use single-cell RNA sequencing and flow cytometry to characterize the phenotypic response of hippocampal astrocytes 2, 4, and 7 days after FUS-BBBO exposure in aged WT and Alzheimer's disease mice. The data presented herein indicate that FUS-BBBO increases gene expression related to synapse modification, neurogenesis, ion transport, and neuronal development. Taken together, these data elucidate a glioprotective role for hippocampal astrocytes following FUS-BBBO, offering mechanistic context and support for previously observed benefits of FUS-BBBO. This evidence critically deepens our understanding of the cellular effects of FUS-BBBO as clinical adoption becomes more widespread.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.