Evidence map›Paper›PMID 40948554›Full record

ArticleiScience2025

Increased levels of syndecan-3 are associated with childhood obesity.

Diego Muñoz-Moreno, Eva Prida, Axel Y Baumann, Raquel Pérez-Lois, Miguel Bascoy, Laura Díaz-Garzón Dopico, Beatriz Brea-García, María Villalón, Rosaura Picans-Leis, Rocío Vázquez-Cobela and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Diego Muñoz-MorenoGrupo Fisiopatología Endocrina, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
Eva PridaCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Av Monforte de Lemos 3-5, 28029 Madrid, Spain.
Axel Y BaumannGrupo Fisiopatología Endocrina, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
Raquel Pérez-LoisGrupo Fisiopatología Endocrina, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
Miguel BascoyGrupo Fisiopatología Endocrina, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
Laura Díaz-Garzón DopicoCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Av Monforte de Lemos 3-5, 28029 Madrid, Spain.
Beatriz Brea-GarcíaTranslational Endocrinology Group, Endocrinology Section, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)/Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
María VillalónGrupo Fisiopatología Endocrina, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
Rosaura Picans-LeisNeonatology Service, RICORS-SAMID-CIBERER, University Clinical Hospital of Santiago de Compostela, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain.
Rocío Vázquez-CobelaCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Av Monforte de Lemos 3-5, 28029 Madrid, Spain.
Ana Estany-GestalPlataforma de Metodología de la Investigación, Instituto de Investigación de Santiago (IDIS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
Luisa María SeoaneGrupo Fisiopatología Endocrina, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.
Rosaura LeisCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Av Monforte de Lemos 3-5, 28029 Madrid, Spain.
Omar Al-MassadiCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Av Monforte de Lemos 3-5, 28029 Madrid, Spain.
Mar QuiñonesGrupo Fisiopatología Endocrina, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (SERGAS), Travesía da Choupana s/n, Santiago de Compostela, 15706 Galicia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood obesity is considered an important risk factor for developing obesity in adult. Syndecan-3 (SDC3) has recently come into focus as a possible molecular target involved in alterations of energy homeostasis, however, its role in childhood obesity remains undefined. We measured mRNA expression levels of SDC3 in children and adolescents with obesity from peripheral blood mononuclear cells and correlating them with different anthropometric and biochemical parameters. We performed a cross-sectional study involving 143 Caucasian children and adolescents. We found increased SDC3 expression in children and adolescents with obesity. In addition, a positive statistical correlation has been found between the levels of SDC3 with body weight, BMI, BMI

Indexed as

Human metabolismPediatrics

Identifiers

PMID40948554
PMCPMC12432489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.