Evidence map›Paper›PMID 40948526›Full record

ArticleAmerican journal of cancer research2025

Aurora-A inhibits hepatocellular carcinoma cell ferroptosis to mediate immune escape by disrupting phosphatidylethanolamine biosynthesis.

Lei Fan, Yiqian Liu, Yucheng Cai, Xinnan Sun, Jiaxuan Li, Yiyang Xu, Changchun Sun, Shiyun Cui

Abstract read
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lei FanDepartment of General Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing, Jiangsu, P. R. China.
Yiqian LiuDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, P. R. China.
Yucheng CaiNanjing Medical University Nanjing, Jiangsu, P. R. China.
Xinnan SunNanjing Medical University Nanjing, Jiangsu, P. R. China.
Jiaxuan LiNanjing Medical University Nanjing, Jiangsu, P. R. China.
Yiyang XuNanjing Medical University Nanjing, Jiangsu, P. R. China.
Changchun SunDepartment of Oncology, Jingjiang People's Hospital Affiliated to Yangzhou University Jingjiang, Jiangsu, P. R. China.
Shiyun CuiDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to explore Aurora-A's role in regulating immune escape of hepatocellular carcinoma (HCC). We performed non-targeted metabolomics analysis and analyzed the impact of Aurora-A inhibitor Alisertib on anti-PD-1 therapy efficacy on xenograft tumors and co-culture models of CD8

Indexed as

Aurora-AferroptosisHCCimmune escapeMAMs formation

Identifiers

PMID40948526
PMCPMC12432570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.