ArticlePharmacogenomics
A genome-wide association study of stroke risk in Asian statin users: evidence from KoGES and UK Biobank.
Article in Pharmacogenomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
7 authors.
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Abstract
backgroundDespite proven efficacy of statins in stroke prevention, genetic factors may influence individual stroke risk among statin users. With increasing precision medicine approaches and growing evidence of population-specific genetic variations, identifying genetic markers that predict stroke risk in statin-treated Asian populations has become critically important for personalized cardiovascular prevention strategies.
methodsWe conducted a genome-wide association study of 1,678 participants using lipid-lowering agents in the Korean Genome and Epidemiology Study (KoGES) cohort. Significant findings were replicated in 2,170 Asian participants on statins from the UK Biobank using an additive genetic model adjusted for relevant covariates.
resultsIn the discovery analysis, 83 single nucleotide polymorphisms were suggestively associated with stroke (
conclusionsThis study identified
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