Evidence map›Paper›PMID 40948350›Full record

ArticleChild maltreatment2026

Maternal Childhood Neglect is Linked to Greater Infant Cortisol Levels and Larger Infant Limbic Volumes.

Jennifer E Khoury, Miriam Chasson, Banu Ahtam, Leland L Fleming, Yangming Ou, Michelle Bosquet Enlow, P Ellen Grant, Karlen Lyons-Ruth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child maltreatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Is neglect the first form of threat?Attachment & human development · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer E KhouryDepartment of Psychology, Mount Saint Vincent University, Halifax, NS, Canada.ORCID 0000-0002-6703-4198
Miriam ChassonDepartment of Psychiatry, Cambridge Hospital, Harvard Medical School, Boston, MA, USA.
Banu AhtamDivision of Newborn Medicine, Fetal-Neonatal Neuroimaging & Developmental Science Center, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Leland L FlemingDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA, USA.
Yangming OuDivision of Newborn Medicine, Fetal-Neonatal Neuroimaging & Developmental Science Center, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Michelle Bosquet EnlowDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
P Ellen GrantDivision of Newborn Medicine, Fetal-Neonatal Neuroimaging & Developmental Science Center, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Karlen Lyons-RuthDepartment of Psychiatry, Cambridge Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Neurobiology of Mothering and Infant StressR01HD079484 · NICHD · MCLEAN HOSPITAL · PI BOSQUET ENLOW, MICHELLE A, GRANT, PATRICIA ELLEN · 2015 to 2019
$3.6M
NICHD NIH HHS R01 HD079484
6 · The paper itself

Abstract

Studies have linked maternal childhood maltreatment to altered infant brain volumes, but none have examined infant hypothalamic-pituitary-adrenal (HPA) axis function as a mechanism linking the two domains. Further, studies among older children suggest that childhood abuse and neglect may be associated with different developmental outcomes and thus should be studied separately. Study participants were N = 57 mother-infant dyads, stratified for maternal childhood maltreatment. At 4 months, infant cortisol total output (AUCg) and change (AUCi) were assessed across the Still-Face Paradigm. Under natural sleep, infants completed T1-weighted MRI scans (

Indexed as

Adult Survivors of Child AbuseChild AbuseHydrocortisoneAdultAmygdalaFemaleHippocampusHumansInfantMagnetic Resonance ImagingMaleMother-Child RelationsMothersHydrocortisoneabuseamygdalacortisolinfancyintergenerational transmissionneglect

Identifiers

PMID40948350
PMCPMC12834378

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.