ArticleMovement disorders clinical practice2026
Circadian Rhythms of Sleep-Wake, Thermoregulatory and Cardiovascular Function in Progressive Supranuclear Palsy.
Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Unraveling sleep dysfunction in progressive supranuclear palsy: a pilot study on the role of periodic limb movements in sleep and insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
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Abstract
backgroundThe sleep-wake cycle and the autonomic nervous system (ANS) can be impaired in neurodegenerative diseases.
objectivesTo describe sleep-wake cycle and circadian rhythms of body core temperature (BcT) and cardiovascular parameters in Progressive Supranuclear Palsy (PSP).
methodsWe prospectively recorded 48 hour video-polysomnography, BcT and blood pressure (BP) in 14 PSP patients (disease duration 5.9 ± 2.6 years) under controlled environmental conditions. We analyzed wake-sleep parameters and state-dependent modulation for BcT, BP and heart rate from the last 24 h of recording. Twelve healthy younger controls were used for comparison.
resultsPatients slept less than 5 hours/night with frequent awakenings, daytime naps were shorter than 60 minutes and mainly represented by light sleep resulting in a 24 h sleep deprivation. Patients with PSP slept less compared to younger controls and normative values for age. Only two patients reported excessive daytime sleepiness. There were no significant differences in sleep parameters according to the presence of sleep disorders. Compared to controls, patients showed significantly higher BcT values during wake and sleep. Twelve patients presented an abnormal BP pattern at nighttime.
conclusionPSP patients experienced profound sleep deprivation across the 24 h study period. An imbalance between sympathetic and parasympathetic function with sympathetic predominance may be associated with this alteration. Whether this autonomic dysfunction is the primary drive for the sleep-wake cycle disruption or the consequence of sleep loss needs to be elucidated.
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