ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2025
All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Migraine and risk of all-cause mortality and specific cause mortality: a systematic review and meta-analysis.The journal of headache and pain · 2025Pooled it
- ECT is not an invasive therapy.European archives of psychiatry and clinical neuroscience · 2026Article
- Determinants of functional burden pleiotropy and gene dosage responses across human traits.Nature communications · 2026Article
- [Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health].Der Nervenarzt · 2026Review
- Article
- Association between depression and all-cause, cardiovascular, and non-cardiovascular mortality in the Spanish population: a prospective cohort study.Archives of public health = Archives belges de sante publique · 2026Article
- Relative risk and risk factors of all-cause, natural-cause and external-cause mortality after psychiatric hospitalisation: a population-based electronic health-record study in Hong Kong.EClinicalMedicine · 2026Article
- Workplace Harassment and All-Cause Mortality in a Longitudinal Cohort over a 24-Year Period.Occupational Health · 2026Article
- A unified voice for evidence-based psychiatry: a global response to the WHO guidance on ECT.European archives of psychiatry and clinical neuroscience · 2026Article
- Electroconvulsive therapy: improved understanding of long-term risks and benefits from advances in administrative health data.The British journal of psychiatry : the journal of mental science · 2026Review
- Associations between smart health device use and depressive symptoms in older adults from the China longitudinal aging social survey.Archives of public health = Archives belges de sante publique · 2026Article
- Response to Kellner, Espinoza, Gligorovic, and Sartorius.Psychological medicine · 2026Article
- Association of Borderline Personality Disorder with Physical Diseases and Mortality: A 16-Year Population-Based Electronic Health-Record Cohort Study in Hong Kong.Psychotherapy and psychosomatics · 2026Article
- Effectiveness of Hybrid AI and Human Suicide Detection Within Digital Peer Support.Journal of clinical medicine · 2026Article
- Antidepressant and anxiolytic medications and risk of mortality in people with dementia: A nested case-control study in Northern Ireland.Journal of Alzheimer's disease : JAD · 2026Article
- Stanford neuromodulation therapy for treatment-resistant depression: a randomized controlled trial confirming efficacy, and an EEG study providing insight into mechanism of action and a potentially predictive biomarker of efficacy.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Representation and outcomes of individuals with major depression in routine care who are ineligible for randomized controlled trials: a nationwide register-based study.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Real-World Effectiveness and Cost-Differential of Intranasal Esketamine Versus Intramuscular Ketamine.Psychiatric research and clinical practice · 2026Article
- The Association Between Depression and Survival in Asthma: The Mediating Role of Income.Depression and anxiety · 2026Article
- Association of vitamin D deficiency with incident depression in patients with hearing impairment: an observational retrospective cohort study.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression has been reported to be associated with premature mortality. However, no meta-analysis has comprehensively examined all-cause and cause-specific mortality risk in people with this condition, focusing also on possible aggravating and attenuating factors, including antidepressant treatment. We conducted a systematic review and meta-analysis of cohort studies to synthesize mortality risk estimates associated with depression (major depressive disorder and dysthymia) due to any and specific causes, and when depression is accompanied by comorbid conditions. Effects of antidepressant medication and electroconvulsive therapy (ECT), and other potential moderators of mortality risk, were evaluated. We searched EMBASE, Medline and PsycINFO databases up to January 26, 2025, pooling mortality estimates using random-effect models. Publication bias, subgroup and meta-regression analyses, and quality assessment (Newcastle-Ottawa Scale) were performed. Across 268 studies, 10,842,094 individuals with depression and 2,837,933,536 control subjects were included. All-cause mortality was doubled in people with depression versus no depression/general population controls (relative risk, RR=2.10, 95% CI: 1.87-2.35, I
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