ArticleJournal of cosmetic dermatology2025
A Prospective, Open-Label, Post Marketing Study of the Safety and Effectiveness of a Hyaluronic Acid and Calcium Hydroxyapatite Hybrid Injectable.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global Recommendations for Facial Rejuvenation Using a Hyaluronic Acid and Calcium Hydroxyapatite Hybrid Injectable.Journal of cosmetic dermatology · 2026Guideline
- A Prospective, Open-Label, Post Marketing Study of the Safety and Effectiveness of a Hyaluronic Acid and Calcium Hydroxyapatite Hybrid Injectable.Journal of cosmetic dermatology · 2025Article
- Evaluating the Properties of a Dual-Effect Facial Injectable: From Preclinical Data to Real-World Evidence.Clinical, cosmetic and investigational dermatology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundHA-CaHA is a hybrid injectable combining hyaluronic acid and calcium hydroxyapatite for dual-mode facial soft tissue augmentation. HA-CaHA-L includes 0.3% lidocaine HCL.
objectiveThis prospective, open-label study evaluated the effectiveness and safety of HA-CaHA for treating midface volume deficit.
methodsAdults rated Moderate to Severe on the Allergan Midface Volume Deficit Scale (MFVDS) received HA-CaHA (n = 110) or HA-CaHA-L (n = 30) in the cheek (primary injection region) and jawline (optional) areas, with optional touch-up 2 weeks later. Follow-up visits occurred at Months 1, 3, 6, 9, and 12. The primary endpoint was the MFVDS responder rate (≥ 1-grade improvement from baseline) at Month 1. Secondary endpoints were the Global Aesthetic Improvement Scale (GAIS) responder rates and change from baseline on FACE-Q Satisfaction with Cheeks and Satisfaction with Facial Appearance. Exploratory endpoints were the Allergan Cheek Smoothness Scale (ACSS) scores and 3D photo-based midface movement tracking. Safety was assessed throughout.
resultsAt Month 1, MFVDS responder rate was 82.8%, remaining high through Month 12. The GAIS responder rates were 98.5% (investigator-rated) and 91.8% (participant-rated) at Month 1, remaining high through Month 12. FACE-Q scores improved 33.3 (Cheeks) and 23.8 (Facial Appearance) points at Month 1, remaining high through Month 12. ACSS scores peaked at Months 3 (73.7%) and 6 (69.2%), with corresponding skin movement changes. Most participants (95.7%) experienced mild or moderate ISRs. The most common treatment-related AEs were injection site pain (11.4%), injection site mass (10.7%), and headache (7.1%).
conclusionsHA-CaHA and HA-CaHA-L are effective and well-tolerated for midface soft tissue augmentation, lasting up to 1 year.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.