Evidence map›Paper›PMID 40947967›Full record

ArticleJournal of dental research2026

Smoking-Associated DNA Methylation and Offspring Caries Experience: Findings from the GUSTO Study.

A A Akinkugbe, C-Y S Hsu, C Lesseur, V Midya, K H Tan, K Y Jerry Chan, J G Eriksson, S-Y Chan, Y S Chong, Y S Lee and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

A A AkinkugbeDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-1207-9732
C-Y S HsuFaculty of Dentistry, National University of Singapore, Singapore.ORCID 0000-0001-7367-3204
C LesseurDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
V MidyaDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
K H TanKK Women's and Children's Hospital (KKH).
K Y Jerry ChanKK Women's and Children's Hospital (KKH).
J G ErikssonInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore.
S-Y ChanInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore.
Y S ChongInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore.
Y S LeeInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-1253-0557
D WangInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore.
J HuangOffice of Public Health Studies, Thompson School of Social Work & Public Health, University of Hawaii at Manoa, Honolulu, Hawaii.
R O WrightDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
N KarnaniInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore.
K M GodfreyMRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust.
A L TehInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore.
R J WrightDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Scholars in Environmental Pediatrics, Reproductive Health, and Life Course ScienceK12ES033594 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$2.3M
Medical Research Council MC_UU_12011/4NIDCR NIH HHS L40 DE028120NIEHS NIH HHS K12 ES033594
6 · The paper itself

Abstract

Self-reported smoking during pregnancy is subject to measurement error, bringing into question previously reported associations with offspring caries experience. We evaluated whether a previously identified prenatal smoking-associated DNA methylation (DNAm) signature, and separately gestational smoking indexed through self-report and plasma cotinine, was associated with offspring caries. The Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort (

Indexed as

Dental CariesDNA MethylationPrenatal Exposure Delayed EffectsSmokingAdultChild, PreschoolCohort StudiesCotinineDMF IndexFemaleHumansMalePregnancyRisk FactorsSingaporeCotininedental cariesEpigeneticsmethylation risk scoreprenatal smokingzero-inflated models

Identifiers

PMID40947967
PMCPMC13200215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.