ArticleEuropean journal of neurology2025
Relieving Chronic Neuropathic Pain With EEG-Neurofeedback.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Quantitative electroencephalography as a next-generation tool in neurodiagnostics: significance, clinical applications, and practical interpretative frameworks.Frontiers in neuroscience · 2026Review
- Relieving Chronic Neuropathic Pain With EEG-Neurofeedback.European journal of neurology · 2025Article
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Authors and funding
10 authors.
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Abstract
backgroundElectroencephalography (EEG)-guided neurofeedback (NFB) is a rarely evaluated neuromodulation technique for the treatment of chronic neuropathic pain.
methodsThe analgesic efficacy of EEG-NFB based on two different EEG targets was assessed in two groups of 16 patients with peripheral neuropathic pain. Twelve EEG-NFB sessions were performed over 4 weeks to improve the β1/β2 or α/θ ratio in the EEG signal of the central cortical region contralateral to the pain side. Before and 1 week after treatment, pain interference with daily life (primary endpoint), pain intensity, neuropathic symptom profile, pain catastrophizing, anxiety, depression, fatigue, and sleep quality were evaluated. In addition, EEG was recorded in the resting state before and after EEG-NFB sessions, as well as during the sessions.
resultsSignificant analgesic effects were observed on the primary endpoint in both groups. However, β1/β2 training specifically reduced the intensity of ongoing and evoked pain, while anxiety and depression were reduced after α/θ training. Responders to β1/β2 training increased β1 activities or β1/β2 ratio in the resting state or during the EEG-NFB sessions, while an increase in the β1/β2 ratio was also observed during the sessions in responders to α/θ training. In 12 of the 15 responders, a transfer task was performed and showed partial maintenance of therapeutic benefit.
conclusionsEEG-NFB can produce analgesia with different clinical and neurophysiological impacts according to various EEG targets. These results open perspectives for the use of EEG-NFB protocols in the treatment of chronic neuropathic pain, based on well-defined EEG targets.
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