ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2026
Influence of Different Parameters on the Labeling Efficiency of Technetium-99m Radiopharmaceuticals: Kuwait Nuclear Medicine Departments Experiences.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe objective of this study was to evaluate the effects of temperature, light, pH, reducing agents, oxygen, dilution, syringe material, solvents, and operator differences on the labeling efficiency of 99mTc-radiopharmaceuticals.
methodsFive GE Healthcare kits ([99mTc]Tc-HMPAO, [99mTc]Tc-MAA, [99mTc]Tc-DMSA, [99mTc]Tc-DTPA, and [99mTc]Tc-tin colloid) were reconstituted with 99mTc-pertechnetate in saline and tested under varying conditions.
resultsLabeling efficiency was largely unaffected, except for [99mTc]Tc-HMPAO, which showed significant reductions with temperature changes (p < 0.001). UV light significantly degraded labeling in all kits (p < 0.001), and pH changes reduced [99mTc]Tc-DMSA efficiency.
conclusionStability depends on optimized formulation, storage, and preparation, and shelf-life extension may be feasible under controlled conditions.
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