ArticleAnimal models and experimental medicine2026
Definition of critical skin defect and concepts of structural and functional repairs: Proposal and verification in a rat model.
Article in Animal models and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1-mediated P53 ubiquitination.Animal models and experimental medicine · 2026Article
- Definition of critical skin defect and concepts of structural and functional repairs: Proposal and verification in a rat model.Animal models and experimental medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundRats are often used to prepare skin defect models. However, the skin defect sizes of the models prepared by researchers are different, and the lack of consensus on the critical-size defect makes it difficult to compare their research results.
methodsThe time for wound closure was evaluated and recorded through gross observation. The regression equation between the healing time and the diameter of skin defect was established, which can be used to predict the healing time for a certain skin defect size in rats. Histochemical and immunohistochemical staining was used to observe the regeneration and reconstruction of skin appendages, and the functional skin repair was quantitatively scored.
resultsThe critical-size defect of rats was determined based on the maximum capacity of structural skin repair, and the functional skin repair was quantitatively scored based on the regeneration and reconstruction of skin appendages. The allowable range of critical-size skin defect of SD rats lies between 45 and 50 mm in diameter. The concept of structural repair and the category of functional repair of injured skin are put forward. The regression equation between the structural skin healing time and defect diameters is established.
conclusionThe allowable range of skin critical-size defect of SD rats lies between 45 and 50 mm in diameter. The regression equation between the structural skin healing time and defect diameters can be used to predict the healing time for a certain skin defect size in rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.