Evidence map›Paper›PMID 40947759›Full record

ArticleParasite immunology2025

In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis.

Caroline de Heleno Chagas de Carvalho, Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Vania Lucia da Ribeiro da Matta, Carolina de Esteves de Morais, Ricardo Romiti, Walter Belda Júnior, Márcia Dalastra Laurenti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasite immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline de Heleno Chagas de CarvalhoDepartamento de Dermatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-2835-3724
Gabriela Venicia Araujo FloresLaboratório de Patologia de Moléstias Infcciosas (LIM-50), Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-8560-7298
Carmen Maria Sandoval PachecoLaboratório de Patologia de Moléstias Infcciosas (LIM-50), Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-6566-4869
Vania Lucia da Ribeiro da MattaLaboratório de Patologia de Moléstias Infcciosas (LIM-50), Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-3509-6121
Carolina de Esteves de MoraisDepartamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-8889-2805
Ricardo RomitiDepartamento de Dermatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-0165-3831
Walter Belda JúniorDepartamento de Dermatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-0401-1885
Márcia Dalastra LaurentiLaboratório de Patologia de Moléstias Infcciosas (LIM-50), Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-1080-2440

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) #30881/2021Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) #2014/50315-0
6 · The paper itself

Abstract

American tegumentary leishmaniasis (ATL) affects the skin and mucous membranes, with a spectrum shaped by Th1/Th2 responses. This study investigated inflammasome activation in correlation with macrophage subpopulations, tissue parasitism, and histological changes in cutaneous and mucocutaneous leishmaniasis. We assessed inflammasome activation, tissue parasitism, and macrophage populations by immunohistochemistry, correlating with histopathological alterations using 29 biopsies from cutaneous and mucocutaneous leishmaniasis. Cutaneous leishmaniasis showed higher parasite density and infected macrophages than mucocutaneous leishmaniasis skin and mucosal lesions (p < 0.05). CD68

Indexed as

InflammasomesLeishmaniasis, CutaneousLeishmaniasis, MucocutaneousMacrophagesAdolescentAdultAgedAntigens, CDAntigens, Differentiation, MyelomonocyticCaspase 1CD163 AntigenFemaleHumansImmunohistochemistryInterleukin-18Interleukin-1betaAntigens, CDAntigens, Differentiation, MyelomonocyticCaspase 1CD163 AntigenInflammasomesInterleukin-18Interleukin-1betaReceptors, Cell Surfacecutaneous leishmaniasishistopathologyimmunohistochemistryinflammasomemacrophagesmucocutaneous leishmaniasis

Identifiers

PMID40947759
PMCPMC12434389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.