ArticleProtein and peptide letters2025
Evaluation of the Cardioprotective Potential of
Article in Protein and peptide letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDiabetic hyperglycemia is often associated with elevated levels of trimethylamine-N-oxide (TMAO), a gut microbiota-derived metabolite that was recently identified as a risk factor for cardiovascular diseases. The combined presence of hyperglycemia and TMAO can aggravate cardiac dysfunction in diabetic patients. This study aimed to evaluate the protective effects of the methanolic extract of
methodsRat cardiomyocytes, H9C2 were exposed to high glucose and TMAO, individually and in combination to simulate diabetic and dysbiotic stress conditions. Cells were treated with optimized doses of Syzygium aromaticum extract under dual-stress conditions. Cellular and nuclear morphology were assessed microscopically. Oxidative stress markers were evaluated. Proteomic profiling using liquid chromatography-mass spectrometry (LC-MS) was conducted to identify differentially expressed proteins. Crucial targets were identified and functionally annotated using integrated bioinformatics tools and databases. Expression of the critical transcription factor Yin- Yang-1 (YY1) was analysed using quantitative PCR (qPCR).
resultsDual exposure to TMAO and hyperglycemia resulted in greater morphological and oxidative damage compared to exposure to either individual stressor alone. Treatment with DISCUSSION: Our findings suggest that
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