Evidence map›Paper›PMID 40947679›Full record

ReviewCurrent neuropharmacology2026

Advances in the Mechanism of ceRNA Regulation in Postoperative Cognitive Dysfunction.

Qiang Liu, Lin-Hui Ma, Chen-Rui Zhou, Tian-Qi Chen, Wei-Feng Wu, Hui-Hui Miao, Yu-Qing Wu, Cheng-Hua Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiang LiuDepartment of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China.
Lin-Hui MaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Chen-Rui ZhouJiangsu Province Key Laboratory of Anesthesiology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, 221004, China.
Tian-Qi ChenJiangsu Province Key Laboratory of Anesthesiology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, 221004, China.
Wei-Feng WuDepartment of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China.
Hui-Hui MiaoDepartment of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Yu-Qing WuJiangsu Province Key Laboratory of Anesthesiology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, 221004, China.
Cheng-Hua ZhouJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.

Funding

National Natural Science Foundation of China (NSFC) 82371211,82171191,82071180
6 · The paper itself

Abstract

Postoperative cognitive dysfunction (POCD) is a common central nervous system complication in elderly patients after surgery, characterized by cognitive changes, including impaired learning and memory, reduced attention, and mental disorders and personality changes in severe cases. Despite extensive research, effective targeted therapies remain elusive, underscoring the urgent need to elucidate their molecular mechanisms and identify novel therapeutic targets. Non-coding RNAs (ncRNAs), major transcription products of the human genome, are highly expressed in the central nervous system and play critical roles in regulating neuronal and synaptic complexity through interactions with other biomolecules. Notably, certain ncRNAs modulate gene expression networks by regulating miRNAs, a phenomenon known as the competing endogenous RNA (ceRNA) mechanism. In this review, we summarized and analyzed emerging evidence on ceRNA-mediated regulatory mechanisms in POCD pathogenesis, aiming to establish a foundation for future mechanistic exploration and therapeutic development.

Indexed as

Postoperative Cognitive ComplicationsRNA, Competitive EndogenousAnimalsGene Expression RegulationHumansMicroRNAsRNA, UntranslatedMicroRNAsRNA, Competitive EndogenousRNA, Untranslatedcentral nervous systemcircular RNAcompeting endogenous RNAslong non-coding RNAmicroRNAPostoperative cognitive dysfunction

Identifiers

PMID40947679
PMCPMC13523327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.