ArticleJournal of surgical oncology2025
Effect of Neoadjuvant Hormonal Therapy on Breast Conservation in Invasive Ductal Versus Lobular Carcinoma of the Breast: A Comparative Analysis.
Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Locoregional Considerations for Invasive Lobular Carcinoma.Current breast cancer reports · 2026Review
- Effect of Neoadjuvant Hormonal Therapy on Breast Conservation in Invasive Ductal Versus Lobular Carcinoma of the Breast: A Comparative Analysis.Journal of surgical oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundComparative efficacy of neoadjuvant hormonal therapy in downstaging invasive ductal carcinoma (IDC) versus invasive lobular carcinoma (ILC) remains an area of uncertainty and may impact primary breast conservation rates.
methodsThe National Cancer Database was used to identify women with IDC and ILC who underwent neoadjuvant hormonal therapy alone between 2004 and 2020. Clinical and pathological T-staging were examined and patients that downstaged before surgery were identified. Univariate and multivariate comparison analyses were performed. The effect of duration of neoadjuvant hormonal therapy was also examined.
resultsAmong women with IDC, 39.5% had lesions that downstaged compared to 30.0% with ILC (p < 0.001). Overall, the duration of neoadjuvant hormonal therapy was longer in patients with downstaged lesions compared to those that did not (mean = 126.9 v 99.4 days; p < 0.001). Of those who downstaged, 43% of patients with IDC and 57.8% of patients with ILC underwent mastectomy following neoadjuvant hormonal therapy.
conclusionsOverall, ILC lesions are less likely to downstage after neoadjuvant hormonal therapy alone compared to IDC lesions. In both histologic subtypes, cancers were more likely to downstage after over 120 days of neoadjuvant hormonal therapy. Clinicians should be mindful when counseling patients that neoadjuvant hormonal therapy alone may not preclude the need for mastectomy in ILC.
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