ArticleBiotechnology and bioengineering2025
M/G-Ratio-Tuned Calcium Alginate Hydrogel Microcarrier for Controlled Delivery of Adeno-Associated Virus for Gene Therapy.
Article in Biotechnology and bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Hydrogel Microtube Drug Carrier for Catheter-Based Intravascular Therapy.Advanced healthcare materials · 2026Article
- M/G-Ratio-Tuned Calcium Alginate Hydrogel Microcarrier for Controlled Delivery of Adeno-Associated Virus for Gene Therapy.Biotechnology and bioengineering · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This paper proposes the controlled release of adeno-associated virus (AAV) by polymer mesh structures of alginate hydrogel microbeads (gel-beads). The polymer mesh structure of alginate hydrogel can be controlled by adjusting the number of cross-linking points depending on the molecular structure (M/G ratio) of the alginate hydrogel. Scanning electron microscopic analysis on the mesh structures of alginate hydrogels with M/G ratios of 0.96 (MG-0.96) and 0.42 (MG-0.42) indicates that the mesh size distribution of MG-0.42 hydrogel was smaller than that of MG-0.96 hydrogel. Using these characteristics, controlled release of AAVs (AAV-1 or AAV-5) from M/G-ratio-tuned gel-beads (MG-0.96 or MG-0.42), Janus-shaped gel-beads consisting of hemispheres of the MG-0.96 and MG-0.42, and MG-0.64 gel-beads consisting of a mixture of MG-0.96 and MG-0.42 were examined with ELISA for AAV capsids and the GFP fluorescent signals from the transfected cells. The precise control of AAV release by the mesh structure of the alginate hydrogels could be an effective method for creating AAV micro-carriers for gene therapy.
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Registered trials
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