Evidence map›Paper›PMID 40947588›Full record

ArticleThe American journal on addictions2026

Persisting high rates of mental health disorders in patients in opioid agonist treatment-Results from a 6-year longitudinal study.

Michael Soyka, Gabi Koller, Wittchen Hans-Ulrich, Gerhard Bühringer

Abstract read
In one paragraph

Article in The American journal on addictions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael SoykaDepartment of Psychiatry and Psychotherapy, Psychiatric Hospital, University of Munich, Munich, Germany.
Gabi KollerDepartment of Psychiatry and Psychotherapy, Psychiatric Hospital, University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0003-0657-5051
Wittchen Hans-UlrichDepartment of Psychiatry and Psychotherapy, Psychiatric Hospital, University of Munich, Munich, Germany.
Gerhard BühringerDepartment of Psychology, Technical University of Dresden, Munich, Germany.

Funding

Bundesministerium für Gesundheit Förderkennzeichen IIA2-2507DSM411
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThere are hardly any data from longitudinal studies on the prevalence of mental health disorders in patients in opioid agonist therapy (OAT).

methodsHere we report prevalence rates of mental health disorders in a 6-year naturalistic noninterventional follow-up study of patients in OAT (N = 2694 at baseline).

resultsThe number of participants without any psychiatric diagnosis only modestly increased from 36.7% to 42.2% (males 42.6%, females 47.6%) over a 6-year period. Depression (42%), anxiety disorders (19.3%), sleep disorders (21.3%), and posttraumatic stress disorder (13%) were most frequent. The rates for patients in psychiatric or psychological/psychotherapeutic treatment at baseline were rather low (8% resp. 8-12%) and declined over time (3.6% resp. 5.4%-6.8% after 6 years). CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Data from this long-term study indicate an overall high persisting prevalence of mental health disorders in patients in OAT and a rather low number of patients in psychiatric/psychological treatment. Hence, this study indicates a substantial need for specific psychosocial and psychopharmacological interventions in patients in opioid agonist therapy.

Indexed as

Analgesics, OpioidMental DisordersOpiate Substitution TreatmentOpioid-Related DisordersAdultFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPrevalenceAnalgesics, Opioid

Identifiers

PMID40947588
PMCPMC12747695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.