Evidence map›Paper›PMID 40947586›Full record

ReviewExpert reviews in molecular medicine2025

Potential Noninvasive Biomarkers to Assess the Aging Process.

Álvaro Pérez Muñoz, Alejandro Gonzalez-Serna, Mercedes Cano

Abstract readReview
In one paragraph

Review in Expert reviews in molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Álvaro Pérez MuñozDepartment of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain.
Alejandro Gonzalez-SernaDepartment of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain.ORCID 0000-0002-0239-8417
Mercedes CanoDepartment of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain.ORCID 0000-0002-7710-0072

Funding

Ministerio de Universidades CNS2022-136054
6 · The paper itself

Abstract

Aging is a process preserved in all living beings, progressive over time and inexorable. Despite the existence of several theories that attempt to explain changes associated with aging, scientists have not managed to satisfactorily explain the causes of aging. However, during the last decade, several cellular processes involved in the aging process have been shown to be involved, allowing scientists to identify new biomolecules as aging biomarkers and control the progression of aging. Currently, there is no single biomarker sensitive and specific enough to predict aging, so it is necessary to find a set of specific biomarkers of cellular processes involved in aging. These biomarkers must be accessible for quantification in biological samples in a noninvasive way to implement them in clinical practice. By 2050, it is estimated that approximately one in six people in the world will be over 65 years old, doubling the percentage of population over 60 years old. Therefore, the research of new biomarkers represents a novel strategy to counteract against aging and improve quality of life. In this review we summarize the potential biomarkers of aging that could be used in a noninvasive manner.

Indexed as

AgingAnimalsBiomarkersEpigenesis, GeneticGenomeGenomic InstabilityHumansImmune SystemOxidative StressBiomarkersagingbiomarkersmicrobiotasenescencetelomere shortening

Identifiers

PMID40947586
PMCPMC12558625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.