Evidence map›Paper›PMID 40947534›Full record

ArticleBritish journal of haematology2025

Systemic immune-inflammation index and pan-immune value as prognostic indicators of clinical outcomes in mycosis fungoides: A retrospective cohort study.

Joon Min Jung, Myoung Eun Choi, Ik Jun Moon, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Woo Jin Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joon Min JungDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-3432-8306
Myoung Eun ChoiDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-7514-7873
Ik Jun MoonDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-1123-4166
Chong Hyun WonDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-1997-2240
Sung Eun ChangDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-4225-0414
Mi Woo LeeDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-4669-9454
Woo Jin LeeDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-0549-464X

Funding

Asan Cancer Institute of Asan Medical CenterAsan Institute for Life Sciences, Asan Medical Center 2023IF0001-1
6 · The paper itself

Abstract

Blood inflammatory markers may provide prognostic insights but remain underexplored in mycosis fungoides (MF). To evaluate the prognostic significance of baseline blood inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), monocyte-to-lymphocyte ratio (MLR), pan-inflammation value (PIV) and systemic immune-inflammation index (SII), in MF. This retrospective cohort study included MF patients diagnosed between 1997 and 2024 at a tertiary medical centre. Markers were analysed in relation to MF stage, morphology, overall survival (OS) and progression-free survival (PFS). Among 195 patients, all markers were significantly elevated in advanced-stage MF compared to early-stage MF. Marker levels generally increased from patch to tumour-stage MF but did not distinguish erythrodermic MF from tumour MF. All markers were associated with poor survival outcomes in univariable analysis. However, in multivariable analysis, only PIV and SII independently associated with poor OS and PFS. Patients with high PIV or SII were more likely to exhibit poor prognostic factors, including advanced stage, head and neck involvement and elevated serum lactate dehydrogenase levels, and experienced more frequent disease progression during follow-up. Single-centre retrospective design. Baseline PIV and SII can be significant prognostic markers in MF, offering enhanced risk stratification and guiding clinical management.

Indexed as

Mycosis FungoidesAdultAgedAged, 80 and overFemaleHumansInflammationMaleMiddle AgedNeutrophilsPrognosisRetrospective Studieseosinophil‐to‐lymphocyte ratiomonocyte‐to‐lymphocyte ratiomycosis fungoidesneutrophil‐to‐lymphocyte ratiopan‐inflammation valuesystemic immune‐inflammation index

Identifiers

PMID40947534
PMCPMC12624204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.