ArticleJournal of hepato-biliary-pancreatic sciences2025
Impact of Systemic Lupus Erythematosus (SLE) on Short-Term Outcomes of Cholecystectomy for Acute Cholecystitis: An Analysis of the US National Readmission Database, 2016-2020.
Article in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background/purposeSystemic lupus erythematosus (SLE) may impact surgical outcomes of acute cholecystitis due to immune dysfunction and systemic inflammation. This study evaluated short-term outcomes of cholecystectomy in SLE patients using US Nationwide Readmissions Database data.
methodsAdults (≥ 18 years) admitted with acute cholecystitis who underwent cholecystectomy between 2016 and 2020 were included. Patients with cholecystostomy or missing data were excluded. After 1:4 propensity score matching, multivariable logistic regression assessed associations between SLE and postoperative outcomes, with results reported as adjusted odds ratios (aORs).
resultsA total of 4400 patients were analyzed (880 with SLE; 3520 without). SLE was associated with higher odds of complications (aOR = 1.64, 95% CI: 1.30-2.08, p < 0.001), particularly sepsis (aOR = 2.41, 95% CI: 1.55-3.77, p < 0.001) and acute kidney injury (aOR = 1.64, 95% CI: 1.23-2.18, p = 0.001). SLE patients also had increased 30-day (aOR = 1.59, 95% CI: 1.24-2.03, p < 0.001) and 90-day (aOR = 1.61, 95% CI: 1.31-1.99, p < 0.001) readmission rates, longer hospital stays (β = 1.04 days), and higher costs (β = 13.01, 95% CI: 7.23-18.80, p < 0.001).
conclusionsSLE is independently linked to worse short-term outcomes following cholecystectomy for acute cholecystitis. Tailored perioperative strategies are warranted for this high-risk group.
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