Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Effect of HD-tDCS targeting the DLPFC on cognitive ability and flight simulation performance in healthy adults.
Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of MRI-Navigated Intermittent Theta Burst Stimulation on Task Performance, Subjective Workload, and EEG Responses During Prolonged Simulated Flight: A Randomized Crossover Study.Bioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the effects of high-definition transcranial direct current stimulation (HD-tDCS) on attention, working memory, inhibitory control, and cognitive flexibility in healthy adults, and to examine its association with flight simulation performance.
methodsOne hundred healthy adults aged 18-30 years were randomly assigned to one of four groups: left DLPFC anodal HD-tDCS, right DLPFC anodal HD-tDCS, bilateral DLPFC anodal HD-tDCS, or sham stimulation. Cognitive abilities and flight simulation performance were assessed before and after the intervention.
resultsThe Stroop effect was significantly reduced in the left HD-tDCS group (P = 0.047) and the bilateral HD-tDCS group (P = 0.008). Switching costs decreased significantly in the right HD-tDCS group (P = 0.006) and the bilateral HD-tDCS group (P = 0.027). The bilateral HD-tDCS group also demonstrated significantly improved flight simulation performance (P = 0.014). :
conclusionLeft and bilateral HD-tDCS improved inhibitory control, while right and bilateral HD-tDCS enhanced cognitive flexibility. Bilateral HD-tDCS yielded the most comprehensive benefits, including improved flight simulation performance. SIGNIFICANCE: These findings underscore the potential of bilateral DLPFC anodal HD-tDCS as a non-invasive tool for enhancing cognitive abilities and optimizing performance in high-demand operational contexts such as aviation. The results may inform future applications in cognitive training and neuroergonomics.
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Registered trials
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