Evidence map›Paper›PMID 40947448›Full record

ReviewMicrosystems & nanoengineering2025

Bioelectronic Interfaces and Sensors for Neural Organoids.

Qifei Wang, Xin Dong, Deming Jiang, Shichao Tian, Yong Qiu, Yuxuan Zhu, Jianguo Wu, Shunuo Shang, Yajie Zhang, Ping Wang and 1 more

Abstract readReview
In one paragraph

Review in Microsystems & nanoengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Organoid Brain-Machine-Interface Devices for Central Nervous System Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Janus Synapses as Modular Neurointerfaces.ACS applied materials & interfaces · 2026
    Review
  5. Review
  6. UnravelingFrontiers in bioengineering and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qifei WangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Xin DongDepartment of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Deming JiangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Shichao TianBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Yong QiuBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Yuxuan ZhuBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Jianguo WuBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Shunuo ShangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Yajie ZhangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Ping WangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Liujing ZhuangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China. zhuangliujing@zju.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) No. 82330064, 32250008, 62271443Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LQ24H090008
6 · The paper itself

Abstract

Neural organoids are emerging as promising in vitro models, offering a unique platform to partially recapitulate the structural and functional complexity of the human nervous system. These three-dimensional (3D) constructs, which mimic key aspects of organ architecture, can be reliably derived from pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs). Their ability to faithfully model neural development and disease pathogenesis has positioned them as indispensable tools in neuroscience research. However, to further unleash their potential, there is a pressing need for long-term and stable monitoring of their dynamic functions in a 3D context. This review provides a brief overview on diverse types of neural organoids and their induction protocols. We further highlight recent advancements in bioelectronic interfaces and sensors tailored for 3D culture. Finally, we discuss future directions aimed at advanced methodologies for real-time, multidimensional functional analysis, ultimately paving the way for breakthroughs in understanding neural development and pathology.

Identifiers

PMID40947448
PMCPMC12434145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.