Evidence map›Paper›PMID 40947445›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Role of Preoperative Stress in Myocardial Injury during Noncardiac Surgery in Wistar Rats.

M V Kondashevskaya, E B Manukhina, V V Aleksankina, K A Artemyeva, L V Kaktursky

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

M V KondashevskayaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. marivladiko@mail.ru.
E B ManukhinaInstitute of General Pathology and Pathophysiology, Moscow, Russia.
V V AleksankinaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
K A ArtemyevaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
L V KakturskyAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Four groups of old Wistar rats were used: anesthesia only (An), noncardiac surgery (NS), stress exposure for 5 days followed by NS (SNS), and an intact control. Increases in proinflammatory cytokines and C-reactive protein were not observed within 10 days after surgery, suggesting no inflammation. Stress was evident from the highest corticosterone level in the SNS rats. Myocardial injury after NS (MINS) occurred in the SNS rats as judged from structural and metabolic disorders and an increase in the blood concentration of High-sensitive cardiac troponin I (hs-cTnI). Although ischemic and hypoxic zones in the myocardium were detected in the An and NS rats, the rats did not develop MINS, displaying neither oxidant-antioxidant imbalance nor, most importantly, an increase in hs-cTnI. The study showed for the first time that "simple" aseptic noncardiac surgery in combination with preoperative stress can induce MINS in healthy old Wistar rats. A decrease in superoxide dismutase was proposed as an additional biomarker of MINS.

Indexed as

MyocardiumStress, PhysiologicalSurgical Procedures, OperativeAnimalsCorticosteroneMaleRatsRats, WistarTroponin ICorticosteroneTroponin Ianesthesiahigh-sensitivity cardiac troponin Imetabolic changesmyocardial damage markersmyocardial ischemianoncardiac surgeryWistar rats

Identifiers

PMID40947445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.