ArticleChemphyschem : a European journal of chemical physics and physical chemistry2025
Anion-Π Meets H-Bonding: Tuning Synergy Through the Flexibility-to-Preorganization Transition in Anion Receptor Design.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Anion-Π Meets H-Bonding: Tuning Synergy Through the Flexibility-to-Preorganization Transition in Anion Receptor Design.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
This study focuses on a series of receptors incorporating urea and pentafluoropyridine motifs to investigate the synergistic combination of hydrogen bonding and anion-π interactions for anion recognition. Three receptors with various spacers are synthesized to evaluate the influence of molecular preorganization and rigidity on anion binding. Flexible receptor 1 and rigid receptors 2 and 3 are synthesized following a two-step protocol, involving the construction of the urea fragment from isocyanate precursors and a nucleophilic aromatic substitution to install the tetrafluoropyridine motif as key steps. Computational analyses (density functional theory (DFT), noncovalent interaction (NCI) plots), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry are employed to assess structural features and binding performance. DFT calculations reveal that all receptors allow complexation with chloride through dual urea and π-anion sites. Structural rigidity in receptor 3 shows enhanced binding efficacy due to steric strain and additional CH···Cl
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Registered trials
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