ArticlePoultry science2025
Sophora flavescens Aqueous Extract Suppresses Eimeria tenella-Induced Inflammatory Responses and Regulates MAPK Pathway.
Article in Poultry science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Portulaca oleracea L. extract repairs chicken cecal barrier damage caused by Eimeria tenella.Poultry science · 2026Article
- Dietary iron overload exacerbates intestinal damage induced by Eimeria tenella infection in broilers via impaired barrier integrity and gut microbiota dysbiosis.Poultry science · 2026Article
- DietaryFrontiers in veterinary science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coccidiosis, caused by Eimeria tenella, leads to severe intestinal damage, growth retardation, and significant economic losses in poultry. Drug resistance in conventional anticoccidial treatments has prompted exploration of herbal extracts, with S. flavescens showing promise due to its anti-inflammatory and antiparasitic properties. This study assessed the anticoccidial efficacy of S. flavescens aqueous extract (SFAE) and its modulation of the MAPK signaling pathway in MDBK cells and white-feathered broilers, using four groups: negative control (NC), E. tenella infection (PC), infection + SFAE (PC+SF), and infection + diclazuril (PC+DC). In vivo, compared to the NC group, PC group broilers exhibited significant bloody diarrhea, cecal lesions, and reduced survival (83 %; p < 0.01). The PC+SF group achieved an anticoccidial index of 162.8, with reduced lesions (p < 0.01) and normalized weight gain by day 6 (p > 0.05). HE staining revealed significant villus shedding and inflammation in the PC group (p < 0.01), while the PC+SF group showed intact villi and reduced inflammation (p < 0.01). In vitro, SFAE (10 mg/mL) had no significant effect on MDBK cell viability (p > 0.05). Compared to the NC group, PC group MDBK cells displayed increased p38 and MEK phosphorylation (p < 0.01), which was significantly reduced in the PC+SF group (p < 0.01), with no difference from NC by day 10 (p > 0.05). Serum ELISA showed significantly elevated IL-1β, IL-6, and TNF-α and reduced IL-10 in the PC group (p < 0.01), while the PC+SF group demonstrated highly significant downregulation of pro-inflammatory cytokines and upregulated IL-10 (p < 0.01), with levels comparable to NC by days 6 and 10 (p > 0.05). In vivo qPCR and Western blot analyses confirmed that MAPK pathway components (ERK, MEK, JNK, Raf1, p38) were highly significantly upregulated in the PC group (p < 0.01), which were significantly reduced in the PC+SF group (p < 0.01), ultimately showing no significant difference from the NC group by day 10 (p > 0.05). SFAE effectively mitigates E. tenella-induced damage by suppressing MAPK signaling and inflammation, suggesting its potential as an anticoccidial agent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.