ArticleCell reports2025
Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Decoupling of amygdala-salience circuit associated with negative symptoms in adolescents with early-onset schizophrenia.Psychiatry and clinical neurosciences · 2026Article
- Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Adolescent neurodevelopment of affective and cognitive control, crucial for healthy functioning and impaired transdiagnostically, is supported by refinements between the amygdala and prefrontal cortex (PFC). Due to technical limitations, fronto-amygdala connectivity remains poorly characterized. Here, we leverage multimodal longitudinal 7 T neuroimaging data in 143 healthy participants aged 10-32 to examine developmental trajectories between subject-specific amygdala nuclei and PFC subregions. We find age-related functional connectivity changes between the lateral PFC and basolateral amygdala, ventral portions of the PFC and central amygdala, and the anterior cingulate cortex and corticoamygdaloid transition area. Variability in connectivity strength relates to individual differences in affective and cognitive control. Using a data-driven meta-analytic decoding approach, we find functional specialization across nuclei and development. Together, these data recapitulate amygdala heterogeneity from animal models and inform how diverse subcircuits support adaptive functioning and confer psychiatric risk during developmental windows of heightened plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.