Evidence map›Paper›PMID 40946238›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2025

The Longitudinal Relationship of Loneliness With Frequency and Problematic Use of Alcohol and Cannabis Among Young Adults.

Isaac C Rhew, Jennifer M Cadigan, Katarina Guttmannova, Justin D Caouette, Margaret R Kuklinski, Sabrina Oesterle

Abstract read
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isaac C RhewDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington. Electronic address: rhew@uw.edu.
Jennifer M CadiganDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Katarina GuttmannovaDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Justin D CaouetteUniversity of Washington, Social Development Research Group, Seattle, Washington.
Margaret R KuklinskiUniversity of Washington, Social Development Research Group, Seattle, Washington.
Sabrina OesterleSouthwest Interdisciplinary Research Center, School of Social Work, Arizona State University, Phoenix, Arizona.

Funding

The Community Youth Development Study: A Test of Communities That CareR01DA015183 · NIDA · UNIVERSITY OF WASHINGTON · PI HAWKINS, J DAVID, OESTERLE, SABRINA · 2003 to 2016
$34.0M
The interplay of social, normative, and legal marijuana environments and marijuana and ATOD use from late childhood to young adulthoodR01DA044522 · NIDA · UNIVERSITY OF WASHINGTON · PI KUKLINSKI, MARGARET, OESTERLE, SABRINA · 2018 to 2022
$4.3M
The interplay of social, normative, and legal marijuana environments and marijuana and ATOD use from late childhood to young adulthoodR56DA044522 · NIDA · UNIVERSITY OF WASHINGTON · PI OESTERLE, SABRINA · 2017 to 2017
$350k
NIDA NIH HHS R01 DA015183NIDA NIH HHS R01 DA044522NIDA NIH HHS R56 DA044522
6 · The paper itself

Abstract

purposeDespite theoretical frameworks linking loneliness with substance use and misuse, there is little longitudinal research on this relationship. This study examined lagged associations of loneliness with subsequent frequency and problematic use of alcohol and cannabis among young adults.

methodsData were from 4,407 young adults participating in the Community Youth Development Study. A four-item loneliness measure was assessed at ages 21 and 23 years, and alcohol and cannabis use outcomes were assessed at ages 23 and 26 years. Past-month alcohol and cannabis use frequency were treated as ordinal categorical outcomes, and past-year hazardous alcohol use and cannabis use disorder diagnosis were treated as dichotomous outcomes. Marginal structural modeling was used to account for multiple time-fixed and time-varying confounders, including depressive symptoms, substance use, and other psychosocial factors.

resultsCombined across lagged intervals, there was a statistically significant association of standardized loneliness score with greater cannabis use frequency (odds ratio = 1.13; 95% confidence interval [CI]: 1.06, 1.20) but not alcohol use frequency (odds ratio = 1.01; 95% CI: 0.96, 1.06) at the following study wave. Loneliness was also associated with increased likelihood of hazardous alcohol use (prevalence ratio = 1.10; 95% CI: 1.03, 1.17) and cannabis use disorder (prevalence ratio = 1.20; 95% CI: 1.12, 1.29). DISCUSSION: The findings suggest that loneliness may play a role in increased cannabis use frequency and problematic alcohol and cannabis use. Strategies to reduce loneliness and increase social connection may have downstream effects on reducing the risk of problematic alcohol and cannabis use among young adults.

Indexed as

Alcohol DrinkingAlcoholismLonelinessMarijuana AbuseAdultFemaleHumansLongitudinal StudiesMaleYoung AdultAlcoholCannabisLonelinessSubstance misuseYoung adults

Identifiers

PMID40946238
PMCPMC12674622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.