Evidence map›Paper›PMID 40946210›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2025

Delayed Lubricin Injection Improves Cartilage Repair Tissue Quality in an In Vivo Rabbit Osteochondral Defect Model.

Donghwan Yoon, Karan Vishwanath, John Dankert, James J Butler, Mohammad T Azam, Arianna L Gianakos, Marshall J Colville, Serafina G Lopez, Matthew J Paszek, Heidi L Reesink and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Medial Osteochondral Defect Drives Matrix and Cell Pathology in Compartment-Matched Meniscus.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Donghwan YoonSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-8389-2697
Karan VishwanathDepartment of Materials Science and Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0003-2910-9176
John DankertFoot and Ankle Division, Department of Orthopedic Surgery, New York University Langone Health, New York, New York, USA.
James J ButlerFoot and Ankle Division, Department of Orthopedic Surgery, New York University Langone Health, New York, New York, USA.
Mohammad T AzamFoot and Ankle Division, Department of Orthopedic Surgery, New York University Langone Health, New York, New York, USA.
Arianna L GianakosFoot and Ankle Division, Department of Orthopedic Surgery, New York University Langone Health, New York, New York, USA.
Marshall J ColvilleCollege of Veterinary Medicine, Department of Clinical Sciences, Cornell University, Ithaca, New York, USA.
Serafina G LopezMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-7117-5156
Matthew J PaszekSmith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA.
Heidi L ReesinkCollege of Veterinary Medicine, Department of Clinical Sciences, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-8534-8839
John G KennedyFoot and Ankle Division, Department of Orthopedic Surgery, New York University Langone Health, New York, New York, USA.
Lawrence J BonassarSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0003-1094-6433
Rebecca M IrwinMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-6549-9912

Funding

Combined Engineering and Orthopaedics Training ProgramT32AR078751 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MAHER, SUZANNE A., VAN DER MEULEN, MARJOLEIN C · 2021 to 2025
$1.7M
NIAMS NIH HHS T32 AR078751This study was partially funded by the Arthroscopic Association of North America (J.G.K. and R.M.I.), the Cornell Ignite Fellow for New Venture (M.J.C.), the Cornell Technology Acceleration and Maturation Fund (H.L.R. and M.J.P.), the Cornell Technology Acceleration and Maturation Fund (M.J.C.), the NSF LEAP-HI CMMI 2245367 (L.J.B., H.L.R., and M.J.P.), and the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number T32AR078751 (S.G.L.).
6 · The paper itself

Abstract

Osteochondral lesions (OCL) are common among young patients and often require surgical interventions since cartilage has a poor capacity for self-repair. Bone marrow stimulation (BMS) has been used clinically for decades to treat OCLs, however a persisting challenge with BMS and other cartilage repair strategies is the inferior quality of the resulting fibrocartilaginous repair tissue. Lubrication-based therapies have the potential to improve the quality of cartilage repair tissue as joint lubrication is linked to local cartilage tissue strains and subsequent cellular responses including death and apoptosis. Recently, a full length recombinant human lubricin (rhLubricin) was developed and has been shown to lower friction in cartilage. This study investigated the effect of a single delayed injection of rhLubricin on cartilage repair in an in vivo rabbit OCL model using gross macroscopic evaluation, surface profilometry, histology, and tribology. Moderate improvement in macroscopic scores for cartilage repair were observed. Notably, quantitative analysis of Safranin-O histology showed that rhLubricin treated joints had significantly higher glycosaminoglycan content compared to saline treated joints, and there were no differences in repair integration between groups. Furthermore, rhLubricin treated joints had significantly lower friction coefficients tested across three sliding speeds compared to saline treated joints (rhLubricin: 0.15 ± 0.03 at 0.1 mm/s to 0.12 ± 0.03 at 10 mm/s, Saline: 0.22 ± 0.06 at 0.1 mm/s to 0.19 ± 0.05 at 10 mm/s). Overall, a single delayed injection of rhLubricin improved the quality and lubricating ability of the repair cartilage tissue without inhibiting repair tissue integration.

Indexed as

Cartilage, ArticularGlycoproteinsAnimalsDisease Models, AnimalInjections, Intra-ArticularProteoglycan 4RabbitsRecombinant ProteinsWound HealingGlycoproteinsProteoglycan 4Recombinant Proteinsfrictionhistologylubricationtribosupplementtribosupplementation

Identifiers

PMID40946210
PMCPMC12917763

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.