Evidence map›Paper›PMID 40946203›Full record

SynthesisComprehensive reviews in food science and food safety2025

Enniatin Mycotoxins in Food: A Systematic Review of Global Occurrence, Biosynthesis, and Toxicological Impacts on In Vitro Human Cell Models.

France Coulet, Nolwenn Hymery, Emmanuel Coton, Monika Coton

Abstract readSystematic Review
In one paragraph

Synthesis in Comprehensive reviews in food science and food safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Occurrence and Co-Occurrence of Regulated and Emerging Mycotoxins in Foods Marketed to U.S. Toddlers.International journal of environmental research and public health · 2026
    Article
  4. Review
  5. Article
  6. Combined exposure to emergingFrontiers in toxicology · 2026
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

France CouletUniv. Brest, INRAE, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, Plouzané, France.
Nolwenn HymeryUniv. Brest, INRAE, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, Plouzané, France.
Emmanuel CotonUniv. Brest, INRAE, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, Plouzané, France.
Monika CotonUniv. Brest, INRAE, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, Plouzané, France.ORCID 0009-0009-9901-2733

Funding

University of Brest Doctoral Contract
6 · The paper itself

Abstract

Enniatins (ENNs) are emerging mycotoxins mainly produced by Fusarium species. They frequently contaminate cereals and cereal-based products. Despite their widespread occurrence, these mycotoxins are not yet regulated, but concerns about their potential health effects due to dietary exposure exist. The most prevalent and well-characterized are ENN A, A1, B, and B1. Their ionophoric nature enables them to disrupt cellular ion homeostasis, leading to potent cytotoxic effects. This review is structured into three major sections. First, we provide a comprehensive meta-analysis based on ENNs occurrence in 6916 food samples collected worldwide, between 2004 and 2024, including cereals, products derived from cereals, other products, and baby food and discuss mycotoxin mitigation. Second, we indicate known ENN-producing Fusarium species and performed a gene sequence analysis suggesting that a dedicated biosynthetic gene cluster exists. Finally, we provide an in-depth overview of ENNs toxicity, ranging from cytotoxicity studies to mechanistic insights into their cellular effects. By consolidating current knowledge, this review highlights critical gaps in ENN research and emphasizes the need for further investigations to better understand their health impacts in a regulatory framework.

Indexed as

DepsipeptidesFood ContaminationMycotoxinsEdible GrainFusariumHumansDepsipeptidesenniatinsMycotoxinsbiosynthetic gene clustercerealsenniatinsfood contaminationin vitro toxicitymycotoxins

Identifiers

PMID40946203
PMCPMC12433590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.