Evidence map›Paper›PMID 40946191›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Phospholipid Remodeling and Tri-Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats.

Shaolei Wang, Fengzhi Qiao, Jian He, Jianxin Fu, Tongjie Liu, Huaxi Yi, Qinghai Sheng, Lanwei Zhang, Kai Lin

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shaolei WangState Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Fengzhi QiaoState Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Jian HeNational Center of Technology Innovation for Dairy, Hohhot, 010000, China.
Jianxin FuState Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Tongjie LiuState Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Huaxi YiState Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Qinghai ShengCollege of Food Science and Technology, Hebei Agricultural University, Baoding, 071001, China.
Lanwei ZhangState Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Kai LinState Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.ORCID https://orcid.org/0000-0003-4445-4939

Funding

China Postdoctoral Science Foundation 2024T170863National Center of Technology Innovation for Dairy 2023-KFKT-13 2022-KFKT-8National Natural Science Foundation of China 32402046Shandong Taishan Industry Leading Talent LJNY202101
6 · The paper itself

Abstract

Human milk fat globules (MFG) are critical for cognitive development during early life. Here, the first study is presented to simulate the phospholipid composition of human milk fat globules and reconstruct their tri-layer membrane to evaluate their effects on cognitive function. Humanized milk fat globule membrane phospholipids (MFGM-PL+SM) significantly promoted the proliferation and neuronal differentiation of hippocampal neural progenitor cells (NPC). Transcriptomic and proteomic analyses reveal that MFGM-PL+SM upregulated cholinergic signaling and neurotrophic factor pathways in differentiated NPC. Layer-by-layer deposition produced tri-layer milk fat globules (T-MFG) with enhanced stability and digestibility over single-layer milk fat globules (S-MFG). Formula supplementation with humanized MFG modulated serum metabolite profiles in rat pups, improving neurodevelopment and increasing hippocampal sphingomyelin levels. Moreover, key neurodevelopmental proteins in formula-fed pups approached levels observed in breastfed controls. These findings highlight the potential of humanized MFG to support infant cognitive development and provide insights for designing enriched infant formulas.

Indexed as

CognitionGlycolipidsGlycoproteinsLipid DropletsPhospholipidsAnimalsAnimals, NewbornFemaleHippocampusHumansMilk, HumanNeural Stem CellsRatsRats, Sprague-DawleyGlycolipidsGlycoproteinsmilk fat globulePhospholipidsCognitionHumanized milk fat globulesNeurodevelopmentPhospholipid compositionTri‐layer membrane

Identifiers

PMID40946191
PMCPMC12677656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.