ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Alkaline-Acid Intestine Environment Controlled by A Carbonic Anhydrase Gene Influences Synthesis of Sex Pheromone by Symbionts.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Review
- Seasonal Dynamics Without Reset: Core Microbiota Stability Across Development in a Gall-Dwelling Weevil.Insects · 2026Article
- Alkaline-Acid Intestine Environment Controlled by A Carbonic Anhydrase Gene Influences Synthesis of Sex Pheromone by Symbionts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
The intricate interplay between animals and their intestinal microbes is pivotal in shaping various aspects of animal biology. However, the degree to which hosts can modulate the activity of their intestinal microbes, as well as the underlying molecular mechanisms, remains poorly elucidated. The production of sex pheromones by rectal Bacillus in male Bactrocera dorsalis is triggered by the alkaline intestine environment. An experimental increase in pH lead to more sex pheromone production, or vice versa. pH modulates the synthesis quantity of sex pheromone by exerting an impact on the activity of enzyme synthesizing sex pheromone in Bacillus. Transcriptome analysis shows that a highly expressed carbonic anhydrase (CAh) gene in B. dorsalis is associated with alkaline rectal environment. CAh inhibitor feeding and RNAi targeting the CAh gene lead to a shift from alkaline to acidic conditions within rectum and subsequent decreasing in sex pheromone synthesis and mating. This study provides novel insight into the influence of intestinal environment on intestinal microbes and has significant implication for understanding the molecular mechanism underlying sex pheromone synthesis by symbionts in insects.
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