Evidence map›Paper›PMID 40946181›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Molecular Design of a Naturally Derived Hemostatic Sealant with Prolonged Antimicrobial Activity for Repairing Elastic Organ Injuries.

Saumya Jain, Avijit Baidya, Joshua A Boys, George Z Cheng, Taichiro Imahori, Naoki Kaneko, Nasim Annabi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saumya JainDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID https://orcid.org/0009-0000-4080-4693
Avijit BaidyaDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Joshua A BoysDivision of Cardiothoracic Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA, 92093, USA.
George Z ChengDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Taichiro ImahoriDivision of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Naoki KanekoDivision of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID https://orcid.org/0000-0003-1879-1202

Funding

Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
NIBIB NIH HHS R01 EB023052NIBIB NIH HHS R01-EB023052
6 · The paper itself

Abstract

Hemorrhaging injuries on dynamic internal organs present significant clinical burdens due to their complex nature. To address therapeutic challenges, an injectable, photocrosslinkable, and multifunctional bioadhesive hydrogel comprising methacrylated gelatin (GelMAG), methacrylated dopamine (DMA), and poly(diallyldimethylammonium chloride) (pDDA), named GDP, is engineered. The hydrogel combined underwater adhesion, antimicrobial activity, and hemostatic performance with high elasticity, biomimetic stiffness, and biocompatibility. The GDP hydrogel displayed >200% elongation and ≈50 kPa Young's modulus in tensile tests. The bioadhesive strongly adhered (>40 kPa strength) to skin, outperforming commercial sealants Coseal and Evicel, and could seal various sizes and shapes of injuries created on explanted pig lungs. Broad-spectrum and long-term in vitro antibacterial activity is noted. During in vivo rat liver puncture and tail amputation, GDP achieved significantly reduced blood loss (≈65%) compared to commercial hemostat Surgicel in some cases. In a clinically relevant porcine lung laceration model, GDP sealed large defects and reduced blood loss by 45-55% compared to Surgicel and hemostatic sealant TISSEEL. It also supported enhanced wound closure and tissue regeneration with minimal inflammation. Ultimately, these findings showcased the potential of GDP to act as an elastic, antibacterial, and hemostatic sealant for the repair of multi-dimensional traumatic injuries on soft, dynamic tissues.

Indexed as

Anti-Infective AgentsHemostaticsAnimalsGelatinHydrogelsRatsSwineTissue AdhesivesWound HealingAnti-Infective AgentsGelatinHemostaticsHydrogelsTissue Adhesivesantibacterialbioadhesiveelastichemostaticsealant

Identifiers

PMID40946181
PMCPMC12561306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.